Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission

Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like hydrogen- or metal–hydride-based reductions. Moreover, the strong thermodynamic driving force for B─O bondf ormation enables efficient cleavage of X─O bonds and...

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Detalles Bibliográficos
Autores: Valderrama-Callejón, Raúl, Alonso Montero, María Inés, Cid de la Plata, María Belén
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:dnet:biblosearchi::dfa114306131684831b65a8a16fd8a8e
Acceso en línea:https://hdl.handle.net/10486/774700
https://dx.doi.org/10.1002/ejoc.70523
Access Level:acceso abierto
Palabra clave:B─B bond activation
B─O bond formation
diboron reagents
N─N bond cleavage
N═N reduction
Química
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spelling Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scissionValderrama-Callejón, RaúlAlonso Montero, María InésCid de la Plata, María BelénB─B bond activationB─O bond formationdiboron reagentsN─N bond cleavageN═N reductionQuímicaDiboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like hydrogen- or metal–hydride-based reductions. Moreover, the strong thermodynamic driving force for B─O bondf ormation enables efficient cleavage of X─O bonds and straight forward deoxygenation without the need for external hydrogen sources such as water or alcohol. This intrinsic reactivity can be further enhanced by bases or Lewis-basic additives, including pyridines, which promote B─B bond activation and broaden the scope of transformations accessible under mild conditions. The effectiveness of diboron-mediated X─O bond cleavage naturally raises the question of whether these reagents might also promotethe scission of N─N bonds─a transformation of increasing interest due to the prevalence of N─N motifs in synthetic intermedi-ates, pharmaceuticals, and nitrogen-rich frameworks. This review outlines current understanding of diboron-mediated N═N andN─N bond cleavage and unifies mechanistic and reactivity insights to guide future advances in diboron-based synthetic transformationsWe are grateful for financial support from the Spanish MICIU/AEI/10.13039/501100011033 (grant PID2022-142594NB-I00)WileyDepartamento de Química OrgánicaFacultad de CienciasGobierno de España20262026-05-26research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/774700https://dx.doi.org/10.1002/ejoc.70523reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:biblosearchi::dfa114306131684831b65a8a16fd8a8e2026-06-23T12:46:27Z
dc.title.none.fl_str_mv Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
title Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
spellingShingle Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
Valderrama-Callejón, Raúl
B─B bond activation
B─O bond formation
diboron reagents
N─N bond cleavage
N═N reduction
Química
title_short Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
title_full Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
title_fullStr Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
title_full_unstemmed Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
title_sort Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
dc.creator.none.fl_str_mv Valderrama-Callejón, Raúl
Alonso Montero, María Inés
Cid de la Plata, María Belén
author Valderrama-Callejón, Raúl
author_facet Valderrama-Callejón, Raúl
Alonso Montero, María Inés
Cid de la Plata, María Belén
author_role author
author2 Alonso Montero, María Inés
Cid de la Plata, María Belén
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Química Orgánica
Facultad de Ciencias
Gobierno de España
dc.subject.none.fl_str_mv B─B bond activation
B─O bond formation
diboron reagents
N─N bond cleavage
N═N reduction
Química
topic B─B bond activation
B─O bond formation
diboron reagents
N─N bond cleavage
N═N reduction
Química
description Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like hydrogen- or metal–hydride-based reductions. Moreover, the strong thermodynamic driving force for B─O bondf ormation enables efficient cleavage of X─O bonds and straight forward deoxygenation without the need for external hydrogen sources such as water or alcohol. This intrinsic reactivity can be further enhanced by bases or Lewis-basic additives, including pyridines, which promote B─B bond activation and broaden the scope of transformations accessible under mild conditions. The effectiveness of diboron-mediated X─O bond cleavage naturally raises the question of whether these reagents might also promotethe scission of N─N bonds─a transformation of increasing interest due to the prevalence of N─N motifs in synthetic intermedi-ates, pharmaceuticals, and nitrogen-rich frameworks. This review outlines current understanding of diboron-mediated N═N andN─N bond cleavage and unifies mechanistic and reactivity insights to guide future advances in diboron-based synthetic transformations
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-05-26
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/774700
https://dx.doi.org/10.1002/ejoc.70523
url https://hdl.handle.net/10486/774700
https://dx.doi.org/10.1002/ejoc.70523
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
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