Mechanistic and reactivity insights into diboron-mediated N=N and N-N bond scission
Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like hydrogen- or metal–hydride-based reductions. Moreover, the strong thermodynamic driving force for B─O bondf ormation enables efficient cleavage of X─O bonds and...
| Authors: | , , |
|---|---|
| Format: | article |
| Publication Date: | 2026 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:dnet:biblosearchi::dfa114306131684831b65a8a16fd8a8e |
| Online Access: | https://hdl.handle.net/10486/774700 https://dx.doi.org/10.1002/ejoc.70523 |
| Access Level: | Open access |
| Keyword: | B─B bond activation B─O bond formation diboron reagents N─N bond cleavage N═N reduction Química |
| Summary: | Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like hydrogen- or metal–hydride-based reductions. Moreover, the strong thermodynamic driving force for B─O bondf ormation enables efficient cleavage of X─O bonds and straight forward deoxygenation without the need for external hydrogen sources such as water or alcohol. This intrinsic reactivity can be further enhanced by bases or Lewis-basic additives, including pyridines, which promote B─B bond activation and broaden the scope of transformations accessible under mild conditions. The effectiveness of diboron-mediated X─O bond cleavage naturally raises the question of whether these reagents might also promotethe scission of N─N bonds─a transformation of increasing interest due to the prevalence of N─N motifs in synthetic intermedi-ates, pharmaceuticals, and nitrogen-rich frameworks. This review outlines current understanding of diboron-mediated N═N andN─N bond cleavage and unifies mechanistic and reactivity insights to guide future advances in diboron-based synthetic transformations |
|---|