Exploring the relationship between maternal carbohydrate quality and quantity during pregnancy and early childhood neurodevelopment

Maternal nutrition during pregnancy is key for offspring neurodevelopment. Given the role of glucose in brain function, assessing carbohydrate quantity and quality, including glycemic index (GI), glycemic load (GL) and carbohydrate quality index (CQI), may provide insights into early brain developme...

Descripción completa

Detalles Bibliográficos
Autores: Panisello, Laura, Mateu-Fabregat, Javier, Novau-Ferré, Nil, Ayala-Aldana, Nicolas|||0000-0002-3530-6734, Bernardo-Castro, Sara|||0000-0001-8809-5101, Ferrer, Muriel, Jiménez-Arenas, Pol, Llurba, Elisa|||0000-0003-4048-6407, Lassale, Camille|||0000-0002-9340-2708, Gómez-Roig, María Dolores|||0000-0003-2329-1851, Vioque, Jesús|||0000-0002-2284-148X, González-Palacios, Sandra|||0000-0003-3358-472X, Contreras Rodríguez, Oren|||0000-0001-8922-8084, Foraster, Maria|||0000-0003-4450-4123, Gascon, Mireia|||0000-0003-4537-8472, Sunyer, Jordi, Awad, Camila, Júlvez, Jordi|||0000-0003-0818-4003, Bulló, Mònica|||0000-0002-0218-7046
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::25a74ec5523094547db822a5ffe5c097
Acceso en línea:https://ddd.uab.cat/record/326668
https://dx.doi.org/urn:doi:10.1007/s00394-025-03829-0
Access Level:acceso abierto
Palabra clave:Maternal nutrition
Neurodevelopment
Carbohydrate intake
Glycemic index
Early childhood
Descripción
Sumario:Maternal nutrition during pregnancy is key for offspring neurodevelopment. Given the role of glucose in brain function, assessing carbohydrate quantity and quality, including glycemic index (GI), glycemic load (GL) and carbohydrate quality index (CQI), may provide insights into early brain development. This study examined the associations between maternal dietary carbohydrate intake and neurodevelopmental outcomes in early childhood. The prospective cohort study included 1080 mother-child pairs from the Barcelona Life Study Cohort. Maternal dietary carbohydrate intake, GI, GL and CQI were assessed during mid-pregnancy using a food frequency questionnaire. Child neurodevelopment was evaluated at 8 and 28 months using the Developmental Profile 3 (DP-3) and at 18 months using the Bayley Scales of Infant and Toddler Development (BSID-III). Associations were analyzed using multivariable linear regression models adjusted for relevant maternal and child covariates. Increased maternal carbohydrate intake, GI, and GL were inversely associated with language development (β (95% CI): - 2.67 (- 5.13, - 0.21), - 2.73 (- 5.21, - 0.26), - 3.51 (- 5.96, - 1.07) respectively) and receptive language (β (95% CI): - 0.58 (- 1.07, - 0.08), - 0.54 (- 1.04, - 0.04), - 0.70 (- 1.20, - 0.21) respectively) at 18 months, as measured by the BSID-III, although these associations were attenuated after adjustment for maternal and child covariates. Increased GI and lower CQI were associated with lower gross motor scores (β (95% CI): - 0.49 (- 0.84, - 0.15), 0.39 (0.06, 0.71) respectively) at 18 months (BSID-III), as well as reduced motor development (β (95% CI): - 3.2 (- 5.50, - 0.76), 2.22 (- 0.1, 4.54) respectively) at 8 and 28 months (DP-3). Maternal carbohydrate quality during pregnancy may influence early neurodevelopment, particularly motor outcomes. Emphasizing low-GI, low-GL and high-CQI carbohydrate sources during pregnancy could support favorable developmental trajectories in offspring. The online version contains supplementary material available at 10.1007/s00394-025-03829-0.

Similares en LA Referencia