Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositório: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p15003 |
| Acesso em linha: | https://fisabio.portalinvestigacion.com/publicaciones/15003 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Axial symptoms cognition MNCD classification non-motor symptoms Parkinson's disease quality of life |
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Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of LifeSantos-García Dde Deus Fonticoba TCores Bartolomé CFeal Painceiras MJÍñiguez-Alvarado MCGarcía Díaz IJesús SBuongiorno MTPlanellas LCosgaya MGarcía Caldentey JCaballol NLegarda IHernández Vara JCabo ILópez Manzanares LGonzález Aramburu IÁvila Rivera MAGómez Mayordomo VNogueira VPuente VDotor García-Soto JBorrué CSolano Vila BÁlvarez Sauco MVela LEscalante SCubo ECarrillo Padilla FMartínez Castrillo JCSánchez Alonso PAlonso Losada MGLópez Ariztegui NGastón IKulisevsky JMenéndez González MSeijo MRuiz Martínez JValero CKurtis MGonzález Ardura JAlonso Redondo ROrdás CLópez Díaz LMMcAfee DCalopa MCarrillo FEscamilla Sevilla FFreire-Alvarez EGómez Esteban JCGarcía Ramos RLuquín MRIMartínez-Torres ISesar Ignacio ÁMartinez-Martin PMir PAxial symptomscognitionMNCD classificationnon-motor symptomsParkinson's diseasequality of lifeBackground: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.IOS PRESS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/15003Journal of Parkinsons DiseaseISSN: 18777171ISSNe: 1877718Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p150032026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| spellingShingle |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life Santos-García D Axial symptoms cognition MNCD classification non-motor symptoms Parkinson's disease quality of life |
| title_short |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_full |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_fullStr |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_full_unstemmed |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_sort |
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life |
| dc.creator.none.fl_str_mv |
Santos-García D de Deus Fonticoba T Cores Bartolomé C Feal Painceiras MJ Íñiguez-Alvarado MC García Díaz I Jesús S Buongiorno MT Planellas L Cosgaya M García Caldentey J Caballol N Legarda I Hernández Vara J Cabo I López Manzanares L González Aramburu I Ávila Rivera MA Gómez Mayordomo V Nogueira V Puente V Dotor García-Soto J Borrué C Solano Vila B Álvarez Sauco M Vela L Escalante S Cubo E Carrillo Padilla F Martínez Castrillo JC Sánchez Alonso P Alonso Losada MG López Ariztegui N Gastón I Kulisevsky J Menéndez González M Seijo M Ruiz Martínez J Valero C Kurtis M González Ardura J Alonso Redondo R Ordás C López Díaz LM McAfee D Calopa M Carrillo F Escamilla Sevilla F Freire-Alvarez E Gómez Esteban JC García Ramos R Luquín MRI Martínez-Torres I Sesar Ignacio Á Martinez-Martin P Mir P |
| author |
Santos-García D |
| author_facet |
Santos-García D de Deus Fonticoba T Cores Bartolomé C Feal Painceiras MJ Íñiguez-Alvarado MC García Díaz I Jesús S Buongiorno MT Planellas L Cosgaya M García Caldentey J Caballol N Legarda I Hernández Vara J Cabo I López Manzanares L González Aramburu I Ávila Rivera MA Gómez Mayordomo V Nogueira V Puente V Dotor García-Soto J Borrué C Solano Vila B Álvarez Sauco M Vela L Escalante S Cubo E Carrillo Padilla F Martínez Castrillo JC Sánchez Alonso P Alonso Losada MG López Ariztegui N Gastón I Kulisevsky J Menéndez González M Seijo M Ruiz Martínez J Valero C Kurtis M González Ardura J Alonso Redondo R Ordás C López Díaz LM McAfee D Calopa M Carrillo F Escamilla Sevilla F Freire-Alvarez E Gómez Esteban JC García Ramos R Luquín MRI Martínez-Torres I Sesar Ignacio Á Martinez-Martin P Mir P |
| author_role |
author |
| author2 |
de Deus Fonticoba T Cores Bartolomé C Feal Painceiras MJ Íñiguez-Alvarado MC García Díaz I Jesús S Buongiorno MT Planellas L Cosgaya M García Caldentey J Caballol N Legarda I Hernández Vara J Cabo I López Manzanares L González Aramburu I Ávila Rivera MA Gómez Mayordomo V Nogueira V Puente V Dotor García-Soto J Borrué C Solano Vila B Álvarez Sauco M Vela L Escalante S Cubo E Carrillo Padilla F Martínez Castrillo JC Sánchez Alonso P Alonso Losada MG López Ariztegui N Gastón I Kulisevsky J Menéndez González M Seijo M Ruiz Martínez J Valero C Kurtis M González Ardura J Alonso Redondo R Ordás C López Díaz LM McAfee D Calopa M Carrillo F Escamilla Sevilla F Freire-Alvarez E Gómez Esteban JC García Ramos R Luquín MRI Martínez-Torres I Sesar Ignacio Á Martinez-Martin P Mir P |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Axial symptoms cognition MNCD classification non-motor symptoms Parkinson's disease quality of life |
| topic |
Axial symptoms cognition MNCD classification non-motor symptoms Parkinson's disease quality of life |
| description |
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/15003 |
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https://fisabio.portalinvestigacion.com/publicaciones/15003 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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IOS PRESS |
| publisher.none.fl_str_mv |
IOS PRESS |
| dc.source.none.fl_str_mv |
Journal of Parkinsons Disease ISSN: 18777171 ISSNe: 1877718X reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869423569818091520 |
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15,812429 |