Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals

Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered inte...

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Authors: Pastor Ibáñez, Roque, Blanco Heredia, Juan|||0000-0001-9526-7450, Etcheverry, Florencia, Sánchez Palomino, Sonsoles, Torrents, David
Format: article
Publication Date:2021
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/345995
Online Access:https://hdl.handle.net/2117/345995
https://dx.doi.org/10.3390/nu13041141
Access Level:Open access
Keyword:HIV infections
Lipids.
Gut microbiota
Supplemented Mediterranean diet
Lipids
Lymphocyte subsets
HIV-1
Treg cells
Dieta mediterrània
VIH (Virus)
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
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spelling Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individualsPastor Ibáñez, RoqueBlanco Heredia, Juan|||0000-0001-9526-7450Etcheverry, FlorenciaSánchez Palomino, SonsolesTorrents, DavidHIV infectionsLipids.Gut microbiotaSupplemented Mediterranean dietLipidsLymphocyte subsetsHIV-1Treg cellsDieta mediterràniaVIH (Virus)Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::BioinformàticaObjective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profileThis study was partially supported by the SPANISH AIDS Research Network (RIS) grants RD16/0025/0002 and RD16/0025/0013 integrated in the State Plan for Scientific and Technical Research and Innovation from the General Sub-Directorate for Research Assessment and Promotion, Spanish Carlos III Institute of Health (ISCIII) co-funded by the European Regional Development Fund (ERDF), 6ª Announcement of Gilead Grants in Biomedical Research in HIV, Hepatic, and Hemo-Oncology, the Spanish Ministry of Economy (MINECO) (grant: SAF2015-66193-R), and income from Europe via the Regional Development (FEDER) and CERCA Programme/Generalitat de Catalunya SGR 615 and SGR 653. F.G. has received support from José María Segovia de Arana contracts. N.R. is a Miguel Servet II investigator from the ISCIII [grant CPII19/00025]. M.N.M. is funded by the grant IND2018/BMD-9651.Peer Reviewed"Article signat per 18 autors/es: Roque Pastor-Ibáñez, Juan Blanco-Heredia, Florencia Etcheverry, Sonsoles Sánchez-Palomino, Francisco Díez-Fuertes, Rosa Casas, María Ángeles Navarrete-Muñoz, Sara Castro-Barquero, Constanza Lucero, Irene Fernández, Lorna Leal, José Miguel Benito, Marc Noguera-Julian, Roger Paredes, Norma Rallón, Ramón Estruch, David Torrents and Felipe García"MDPI20212021-01-0120212021-05-21journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/345995https://dx.doi.org/10.3390/nu1304114133808476reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 3.0 Spainhttp://creativecommons.org/licenses/by/3.0/es/Attribution 3.0 Spainhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3459952026-05-27T15:37:01Z
dc.title.none.fl_str_mv Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
title Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
spellingShingle Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
Pastor Ibáñez, Roque
HIV infections
Lipids.
Gut microbiota
Supplemented Mediterranean diet
Lipids
Lymphocyte subsets
HIV-1
Treg cells
Dieta mediterrània
VIH (Virus)
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
title_short Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
title_full Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
title_fullStr Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
title_full_unstemmed Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
title_sort Adherence to a supplemented Mediterranean diet drives changes in the gut microbiota of HIV-1-infected individuals
dc.creator.none.fl_str_mv Pastor Ibáñez, Roque
Blanco Heredia, Juan|||0000-0001-9526-7450
Etcheverry, Florencia
Sánchez Palomino, Sonsoles
Torrents, David
author Pastor Ibáñez, Roque
author_facet Pastor Ibáñez, Roque
Blanco Heredia, Juan|||0000-0001-9526-7450
Etcheverry, Florencia
Sánchez Palomino, Sonsoles
Torrents, David
author_role author
author2 Blanco Heredia, Juan|||0000-0001-9526-7450
Etcheverry, Florencia
Sánchez Palomino, Sonsoles
Torrents, David
author2_role author
author
author
author
dc.subject.none.fl_str_mv HIV infections
Lipids.
Gut microbiota
Supplemented Mediterranean diet
Lipids
Lymphocyte subsets
HIV-1
Treg cells
Dieta mediterrània
VIH (Virus)
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
topic HIV infections
Lipids.
Gut microbiota
Supplemented Mediterranean diet
Lipids
Lymphocyte subsets
HIV-1
Treg cells
Dieta mediterrània
VIH (Virus)
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
description Objective: The health effects of a supplemented Mediterranean diet (SMD) with extra-virgin olive oil (EVOO) and nuts are well documented in non-HIV-infected individuals. We hypothesised that the benefits of an SMD could be mediated by changes in the gut microbiota, even in those with an altered intestinal microbiota such as people living with HIV. Design: Individuals living with HIV (n = 102) were randomised to receive an SMD with 50 g/day of EVOO and 30 g/day of walnuts (SMD group) or continue with their regular diet (control group) for 12 weeks. Methods: Adherence to the Mediterranean diet was assessed using the validated 14-item MD-Adherence-Screener (MEDAS) from the PREDIMED study. A sub-study classifying the participants according to their MEDAS scores was performed. Results: The lipid profile was improved in the SMD group vs. that in the control group (delta-total cholesterol and delta-B-lipoprotein). The immune activation (CD4+HLADR+CD38+ and CD8+HLADR+CD38+ cells) and IFN-γ-producing T-cells significantly decreased at week 12 compared to the baseline in the SMD group but not in the control group. The gut microbiota in those from the high-adherence group presented significantly high diversity and richness at the end of the intervention. Succinivibrio and Bifidobacterium abundances were influenced by the adherence to the MD and significantly correlated with Treg cells. Conclusion: The Mediterranean diet improved metabolic parameters, immune activation, Treg function, and the gut microbiota composition in HIV-1-infected individuals. Further, Mediterranean diet increased the Bifidobacterium abundances after the intervention, and it was associated to a beneficial profile
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-05-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/345995
https://dx.doi.org/10.3390/nu13041141
33808476
url https://hdl.handle.net/2117/345995
https://dx.doi.org/10.3390/nu13041141
identifier_str_mv 33808476
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
Attribution 3.0 Spain
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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