Detection of CI subunits in Ndufs4−/− macrophages [Dataset]

Left panel, Western blot for NDUFV1 (N module) and NDUFA9 (Q module). ATP5B and Coomassie staining were used as loading controls. Right panel, schematic representation of CI. The N module contains an NADH oxidation site, while the Q module contains a ubiquinone reduction site. P module is involved i...

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Detalles Bibliográficos
Autores: Serrano-Lorenzo, Pablo, Gobelli, Dino, Garrido-Moraga, Rocío, Esteban-Amo, María J., López-López, José R., Orduña, Antonio, Fuente, Miguel A. de la, Martín, Miguel Ángel, Simarro-Grande, María
Tipo de recurso: conjunto de datos
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/352335
Acceso en línea:http://hdl.handle.net/10261/352335
Access Level:acceso abierto
Palabra clave:Leigh syndrome patients
Inflammatory cytokine profile
Increasing evidence demonstrate
Div >< p
Mitochondrial respiration alterations
Macrophage effector functions
Effector functions
Maximal respiration Vitro </
Supernumerary subunit
Shift towards
Phagocytose gram
Ndufs4 </
Mutational hotspot
Modulatory role
Lower levels
Lipopolysaccharide challenge
Improved ability
Critical role
Atp production
Descripción
Sumario:Left panel, Western blot for NDUFV1 (N module) and NDUFA9 (Q module). ATP5B and Coomassie staining were used as loading controls. Right panel, schematic representation of CI. The N module contains an NADH oxidation site, while the Q module contains a ubiquinone reduction site. P module is involved in proton-pumping activity. The positions of NDUFV1 and NDUFA9 are indicated. IMM, inner mitochondrial membrane; IMS, intermembrane space.

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