Self-healing, stretchable and robust interpenetrating network hydrogels

A self-healable stretchable hydrogel system that can be readily synthesized while also possessing robust compressive strength has immense potential for regenerative medicine. Herein, we have explored the addition of commercially available unfunctionalized polysaccharides as a route to synthesize sel...

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Autores: Macdougall, Laura, Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485, Shaw, Joshua E., Inam, Maria, Hoyland, Judith A., O'Reilly, Rachel, Richardson, Stephen M., Dove, Andrew
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/366701
Acceso en línea:https://hdl.handle.net/2117/366701
https://dx.doi.org/10.1039/C8BM00872H
Access Level:acceso abierto
Palabra clave:Biomedical materials
Hydrogel
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
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spelling Self-healing, stretchable and robust interpenetrating network hydrogelsMacdougall, LauraPérez Madrigal, Maria del Mar|||0000-0002-2498-8485Shaw, Joshua E.Inam, MariaHoyland, Judith A.O'Reilly, RachelRichardson, Stephen M.Dove, AndrewBiomedical materialsHydrogelMaterials biomèdicsÀrees temàtiques de la UPC::Enginyeria biomèdica::BiomaterialsA self-healable stretchable hydrogel system that can be readily synthesized while also possessing robust compressive strength has immense potential for regenerative medicine. Herein, we have explored the addition of commercially available unfunctionalized polysaccharides as a route to synthesize self-healing, stretchable poly(ethylene glycol) (PEG) interpenetrating networks (IPNs) as extracellular matrix (ECM) mimics. The introduction of self-healing and stretchable properties has been achieved while maintaining the robust mechanical strength of the orginal, single network PEG-only hydrogels (ultimate compressive stress up to 2.4 MPa). This has been accomplished without the need for complicated and expensive functionalization of the natural polymers, enhancing the translational applicability of these new biomaterials.Royal Society of Chemistry (RSC)20182018-01-0120222022-05-03journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/366701https://dx.doi.org/10.1039/C8BM00872Hreponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 3.0 Spainhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3667012026-05-27T15:37:01Z
dc.title.none.fl_str_mv Self-healing, stretchable and robust interpenetrating network hydrogels
title Self-healing, stretchable and robust interpenetrating network hydrogels
spellingShingle Self-healing, stretchable and robust interpenetrating network hydrogels
Macdougall, Laura
Biomedical materials
Hydrogel
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
title_short Self-healing, stretchable and robust interpenetrating network hydrogels
title_full Self-healing, stretchable and robust interpenetrating network hydrogels
title_fullStr Self-healing, stretchable and robust interpenetrating network hydrogels
title_full_unstemmed Self-healing, stretchable and robust interpenetrating network hydrogels
title_sort Self-healing, stretchable and robust interpenetrating network hydrogels
dc.creator.none.fl_str_mv Macdougall, Laura
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Shaw, Joshua E.
Inam, Maria
Hoyland, Judith A.
O'Reilly, Rachel
Richardson, Stephen M.
Dove, Andrew
author Macdougall, Laura
author_facet Macdougall, Laura
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Shaw, Joshua E.
Inam, Maria
Hoyland, Judith A.
O'Reilly, Rachel
Richardson, Stephen M.
Dove, Andrew
author_role author
author2 Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Shaw, Joshua E.
Inam, Maria
Hoyland, Judith A.
O'Reilly, Rachel
Richardson, Stephen M.
Dove, Andrew
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomedical materials
Hydrogel
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
topic Biomedical materials
Hydrogel
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
description A self-healable stretchable hydrogel system that can be readily synthesized while also possessing robust compressive strength has immense potential for regenerative medicine. Herein, we have explored the addition of commercially available unfunctionalized polysaccharides as a route to synthesize self-healing, stretchable poly(ethylene glycol) (PEG) interpenetrating networks (IPNs) as extracellular matrix (ECM) mimics. The introduction of self-healing and stretchable properties has been achieved while maintaining the robust mechanical strength of the orginal, single network PEG-only hydrogels (ultimate compressive stress up to 2.4 MPa). This has been accomplished without the need for complicated and expensive functionalization of the natural polymers, enhancing the translational applicability of these new biomaterials.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2022
2022-05-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/366701
https://dx.doi.org/10.1039/C8BM00872H
url https://hdl.handle.net/2117/366701
https://dx.doi.org/10.1039/C8BM00872H
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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