Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

In this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successfu...

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Detalles Bibliográficos
Autores: Fraioli, Roberta, Neubauer, Stefanie, Rechenmacher, Florian, Bosch Canals, Begoña María, Dashnyam, Khandmaa, Kim, Joong-Hyun, Gil Mur, Francisco Javier|||0000-0002-6824-1412, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Manero Planella, José María|||0000-0002-1673-4389, Mas Moruno, Carlos|||0000-0001-8337-0872
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/178261
Acceso en línea:https://hdl.handle.net/2117/178261
https://dx.doi.org/10.1039/c8bm01466c
Access Level:acceso abierto
Palabra clave:Biomedical materials
Materials biomèdics
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
Descripción
Sumario:In this communication we report that anchoring avß3 or a5ß1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

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