Mediterranean diet and white blood cell count — A randomized controlled trial

We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet inte...

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Detalhes bibliográficos
Autores: Hernáez, Álvaro, Lassale, Camille, Castro-Barquero, Sara, Babio, Nancy, Ros Rahola, Emilio, Castañer, Olga, Tresserra-Rimbau, Anna, Pintó Sala, Xavier, Martínez-González, Miguel Ángel, Corella Piquer, Dolores, Salas Salvadó, Jordi, Alonso Gómez, Ángel M., Lapetra, José, Fiol, Miquel, Gómez-Gracia, Enrique, Serra Majem, Lluís, Sacanella Meseguer, Emilio, García-Arellano, Ana, Sorlí, José V., Díaz López, Andrés, Cofán Pujol, Montserrat, Estruch Riba, Ramon
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/4622
Acesso em linha:http://hdl.handle.net/20.500.14342/4622
https://doi.org/10.3390/foods10061268
Access Level:acceso abierto
Palavra-chave:Leucòcits
Dieta mediterrània
Leucopènia
Leucocitosi
Assaigs clínics
Prevenció
Descrição
Resumo:We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36–0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10–0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085–0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.

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