Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial

There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (...

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Detalles Bibliográficos
Autores: Hernáez, Álvaro, Lassale, Camille, Castro-Barquero, Sara, Ros Rahola, Emilio, Tresserra-Rimbau, Anna, Castañer, Olga, Pintó Sala, Xavier, Vázquez Ruiz, Zenaida, Sorlí, José V., Salas Salvadó, Jordi, Lapetra, José, Gómez-Gracia, Enrique, Alonso Gómez, Ángel M., Fiol, Miquel, Serra Majem, Lluís, Sacanella Meseguer, Emilio, Razquin, Cristina, Corella Piquer, Dolores, Guasch-Ferré, Marta, Cofán Pujol, Montserrat, Estruch Riba, Ramon
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/761
Acceso en línea:http://hdl.handle.net/20.500.14342/761
https://doi.org/10.3390/nu13020559
Access Level:acceso abierto
Palabra clave:Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
613
616.1
Descripción
Sumario:There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.

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