Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015

Background: Concerns have been raised about intraseasonal waning of the protection conferred by influenza vaccination. Methods: During four influenza seasons, we consecutively recruited individuals aged 18 years or older who had received seasonal influenza vaccine and were subsequently admitted to t...

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Autores: Puig-Barbera J, Mira-Iglesias A, Tortajada-Girbes M, Lopez-Labrador FX, Librero-Lopez J, Diez-Domingo J, Carballido-Fernandez M, Carratala-Munuera C, Correcher-Medina P, GIL, V., Limon-Ramirez R, Mollar-Maseres J, Otero-Reigada MC, Schwarz H, Valencia Hospital Network for the Study of Influenza and other Respiratory Virus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p2218
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/2218
Access Level:acceso abierto
Palabra clave:Influenza vaccine
Vaccine effectiveness
Waning protection
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spelling Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015Puig-Barbera JMira-Iglesias ATortajada-Girbes MLopez-Labrador FXLibrero-Lopez JDiez-Domingo JCarballido-Fernandez MCarratala-Munuera CCorrecher-Medina PGIL, V.Limon-Ramirez RMollar-Maseres JOtero-Reigada MCSchwarz HValencia Hospital Network for the Study of Influenza and other Respiratory VirusInfluenza vaccineVaccine effectivenessWaning protectionBackground: Concerns have been raised about intraseasonal waning of the protection conferred by influenza vaccination. Methods: During four influenza seasons, we consecutively recruited individuals aged 18 years or older who had received seasonal influenza vaccine and were subsequently admitted to the hospital for, influenza infection, as assessed by reverse transcription polymerase chain reaction. We estimated the adjusted odds ratio (aOR) of influenza infection by date of vaccination, defined by tertiles, as early, intermediate or late vaccination. We used a test-negative approach with early vaccination as reference to estimate the aOR of hospital admission with influenza among late vaccinees. We conducted sensitivity analyses by means of conditional logistic regression, Cox proportional hazards regression, and using days between vaccination and hospital admission rather than vaccination date. Results: Among 3615 admitted vaccinees, 822 (23%) were positive for influenza. We observed a lower risk of influenza among late vaccinees during the 2011/2012 and 2014/2015A(H3N2)-dominant seasons: aOR = 0.68 (95% CI: 0.47-1.00) and 0.69 (95% CI: 0.50-0.95). We found no differences in the risk of admission with influenza among late versus early vaccinees in the 2012/2013A(H1N1)pdm09-dominant or 2013/2014B/Yamagata lineage -dominant seasons: aOR =1.18 (95% CI: 0.58-2.41) and 0.98 (95% CI: 0,56-1.72). When we restricted our analysis to individuals aged 65 years or older, we found a statistically significant lower risk of admission with influenza among late vaccinees during the 2011/2012 and 2014/2015 A(H3N2)-dominant seasons: aOR = 0.61 (95% CI: 0.41-0.91) and 0.69 (95% CI: 0.49-0.96). We observed 39% (95% CI: 9-59%) and 31% (95% CI: 5-50%) waning of vaccine effectiveness among participants aged 65 years or older during the two A(H3N2)-dominant seasons. Similar results were obtained in the sensitivity analyses. Conclusion: Waning of vaccine protection was observed among individuals aged 65 years old or over in two A(H3N2)-dominant influenza seasons. (C) 2017 The Author(s). Published by Elsevier Ltd.Elsevier BV2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/2218VaccineISSN: 13588745ISSNe: 0264410Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p22182026-06-11T12:45:17Z
dc.title.none.fl_str_mv Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
title Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
spellingShingle Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
Puig-Barbera J
Influenza vaccine
Vaccine effectiveness
Waning protection
title_short Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
title_full Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
title_fullStr Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
title_full_unstemmed Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
title_sort Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015
dc.creator.none.fl_str_mv Puig-Barbera J
Mira-Iglesias A
Tortajada-Girbes M
Lopez-Labrador FX
Librero-Lopez J
Diez-Domingo J
Carballido-Fernandez M
Carratala-Munuera C
Correcher-Medina P
GIL, V.
Limon-Ramirez R
Mollar-Maseres J
Otero-Reigada MC
Schwarz H
Valencia Hospital Network for the Study of Influenza and other Respiratory Virus
author Puig-Barbera J
author_facet Puig-Barbera J
Mira-Iglesias A
Tortajada-Girbes M
Lopez-Labrador FX
Librero-Lopez J
Diez-Domingo J
Carballido-Fernandez M
Carratala-Munuera C
Correcher-Medina P
GIL, V.
Limon-Ramirez R
Mollar-Maseres J
Otero-Reigada MC
Schwarz H
Valencia Hospital Network for the Study of Influenza and other Respiratory Virus
author_role author
author2 Mira-Iglesias A
Tortajada-Girbes M
Lopez-Labrador FX
Librero-Lopez J
Diez-Domingo J
Carballido-Fernandez M
Carratala-Munuera C
Correcher-Medina P
GIL, V.
Limon-Ramirez R
Mollar-Maseres J
Otero-Reigada MC
Schwarz H
Valencia Hospital Network for the Study of Influenza and other Respiratory Virus
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Influenza vaccine
Vaccine effectiveness
Waning protection
topic Influenza vaccine
Vaccine effectiveness
Waning protection
description Background: Concerns have been raised about intraseasonal waning of the protection conferred by influenza vaccination. Methods: During four influenza seasons, we consecutively recruited individuals aged 18 years or older who had received seasonal influenza vaccine and were subsequently admitted to the hospital for, influenza infection, as assessed by reverse transcription polymerase chain reaction. We estimated the adjusted odds ratio (aOR) of influenza infection by date of vaccination, defined by tertiles, as early, intermediate or late vaccination. We used a test-negative approach with early vaccination as reference to estimate the aOR of hospital admission with influenza among late vaccinees. We conducted sensitivity analyses by means of conditional logistic regression, Cox proportional hazards regression, and using days between vaccination and hospital admission rather than vaccination date. Results: Among 3615 admitted vaccinees, 822 (23%) were positive for influenza. We observed a lower risk of influenza among late vaccinees during the 2011/2012 and 2014/2015A(H3N2)-dominant seasons: aOR = 0.68 (95% CI: 0.47-1.00) and 0.69 (95% CI: 0.50-0.95). We found no differences in the risk of admission with influenza among late versus early vaccinees in the 2012/2013A(H1N1)pdm09-dominant or 2013/2014B/Yamagata lineage -dominant seasons: aOR =1.18 (95% CI: 0.58-2.41) and 0.98 (95% CI: 0,56-1.72). When we restricted our analysis to individuals aged 65 years or older, we found a statistically significant lower risk of admission with influenza among late vaccinees during the 2011/2012 and 2014/2015 A(H3N2)-dominant seasons: aOR = 0.61 (95% CI: 0.41-0.91) and 0.69 (95% CI: 0.49-0.96). We observed 39% (95% CI: 9-59%) and 31% (95% CI: 5-50%) waning of vaccine effectiveness among participants aged 65 years or older during the two A(H3N2)-dominant seasons. Similar results were obtained in the sensitivity analyses. Conclusion: Waning of vaccine protection was observed among individuals aged 65 years old or over in two A(H3N2)-dominant influenza seasons. (C) 2017 The Author(s). Published by Elsevier Ltd.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/2218
url https://fisabio.portalinvestigacion.com/publicaciones/2218
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Vaccine
ISSN: 13588745
ISSNe: 0264410X
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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