Effectiveness of influenza vaccine against laboratory-confirmed influenza, in the late 2011-2012 season in Spain, among population targeted for vaccination

Background: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance System. The objective of the study was to estimate influenza vaccine effectivenes...

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Detalles Bibliográficos
Autores: Jiménez Jorge, Silvia, Mateo, Salvador de, Delgado-Sanz, Concha, Pozo Rodríguez, Francisco, Casas, Inmaculada|||0000-0003-1840-1198, García Cenoz, Manuel|||0000-0001-7316-9104, Castilla, Jesus|||0000-0002-6396-7265, Pérez, Esteban, Gallardo-García, Virtudes, Rodriguez, Carolina, Vega, Tomás, Quiñones, Carmen, Martínez, Eva, Vanrell, Juana María, Giménez, Jaume, Castrillejo, Daniel, Serrano, María del Carmen, Mauro Ramos, Julián, Larrauri, Amparo|||0000-0002-1704-2245
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:112680
Acceso en línea:https://ddd.uab.cat/record/112680
https://dx.doi.org/urn:doi:10.1186/1471-2334-13-441
Access Level:acceso abierto
Palabra clave:Influenza
Vaccine effectiveness
Case-control studies
Sentinel networks
Discordant strain
Waning immunity
Descripción
Sumario:Background: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using the observational study cycEVA conducted in the frame of the existing Spanish Influenza Sentinel Surveillance System. The objective of the study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza-like illness (ILI) among the target groups for vaccination in Spain in the 2011-2012 season. We also studied influenza VE in the early (weeks 52/2011-7/2012) and late (weeks 8-14/2012) phases of the epidemic and according to time since vaccination. Methods: Medically attended patients with ILI were systematically swabbed to collect information on exposure, laboratory outcome and confounding factors. Patients belonging to target groups for vaccination and who were swabbed <8 days after symptom onset were included. Cases tested positive for influenza and controls tested negative for any influenza virus. To examine the effect of a late season, analyses were performed according to the phase of the season and according to the time between vaccination and symptoms onset. Results: The overall adjusted influenza VE against A(H3N2) was 45% (95% CI, 0-69). The estimated influenza VE was 52% (95% CI, -3 to 78), 40% (95% CI, -40 to 74) and 22% (95% CI, -135 to 74) at 3.5 months, 3.5-4 months, and.

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