Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells

The mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the substantia nigra (SN) (A9 neurons) and the ventral tegmental area (VTA) (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural r...

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Autores: Biagioli, Marta, Pinto, Milena, Cesselli, Daniela, Zaninello, Marta, Lazarevic, Dejan, Roncaglia, Paola, Simone, Roberto, Vlachouli, Christina, Plessy, Charles, Bertin, Nicolas, Beltrami, Antonio, Kobayashi, Kazuto, Gallo, Vittorio, Santoro, Claudio, Ferrer, Isidro (Ferrer Abizanda), Rivella, Stefano, Beltrami, Carlo Alberto, Carninci, Piero, Raviola, Elio, Gustincich, Stefano
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/141853
Acesso em linha:https://hdl.handle.net/2445/141853
Access Level:acceso abierto
Palavra-chave:Neuròglia
Metabolisme
Neurones
Citologia
Neuroglia
Metabolism
Neurons
Cytology
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spelling Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cellsBiagioli, MartaPinto, MilenaCesselli, DanielaZaninello, MartaLazarevic, DejanRoncaglia, PaolaSimone, RobertoVlachouli, ChristinaPlessy, CharlesBertin, NicolasBeltrami, AntonioKobayashi, KazutoGallo, VittorioSantoro, ClaudioFerrer, Isidro (Ferrer Abizanda)Rivella, StefanoBeltrami, Carlo AlbertoCarninci, PieroRaviola, ElioGustincich, StefanoNeurògliaMetabolismeNeuronesCitologiaNeurogliaMetabolismNeuronsCytologyThe mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the substantia nigra (SN) (A9 neurons) and the ventral tegmental area (VTA) (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Their selective degeneration leads to Parkinson's disease. Here, we report that gene expression analysis of A9 dopaminergic neurons (DA) identifies transcripts for alpha- and beta-chains of hemoglobin (Hb). Globin immunoreactivity decorates the majority of A9 DA, a subpopulation of cortical and hippocampal astrocytes and mature oligodendrocytes. This pattern of expression was confirmed in different mouse strains and in rat and human. We show that Hb is expressed in the SN of human postmortem brain. By microarray analysis of dopaminergic cell lines overexpressing alpha- and beta-globin chains, changes in genes involved in O(2) homeostasis and oxidative phopshorylation were observed, linking Hb expression to mitochondrial function. Our data suggest that the most famed oxygen-carrying globin is not exclusively restricted to the blood, but it may play a role in the normal physiology of the brain and neurodegenerative diseases.National Academy of Sciences2019201920092019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/141853Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1073/pnas.0813216106Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2009, vol. 106, num. 36, p. 15454-15459https://doi.org/10.1073/pnas.0813216106(c) Biagioli, Marta et al., 2009info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1418532026-05-29T05:05:01Z
dc.title.none.fl_str_mv Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
title Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
spellingShingle Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
Biagioli, Marta
Neuròglia
Metabolisme
Neurones
Citologia
Neuroglia
Metabolism
Neurons
Cytology
title_short Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
title_full Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
title_fullStr Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
title_full_unstemmed Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
title_sort Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
dc.creator.none.fl_str_mv Biagioli, Marta
Pinto, Milena
Cesselli, Daniela
Zaninello, Marta
Lazarevic, Dejan
Roncaglia, Paola
Simone, Roberto
Vlachouli, Christina
Plessy, Charles
Bertin, Nicolas
Beltrami, Antonio
Kobayashi, Kazuto
Gallo, Vittorio
Santoro, Claudio
Ferrer, Isidro (Ferrer Abizanda)
Rivella, Stefano
Beltrami, Carlo Alberto
Carninci, Piero
Raviola, Elio
Gustincich, Stefano
author Biagioli, Marta
author_facet Biagioli, Marta
Pinto, Milena
Cesselli, Daniela
Zaninello, Marta
Lazarevic, Dejan
Roncaglia, Paola
Simone, Roberto
Vlachouli, Christina
Plessy, Charles
Bertin, Nicolas
Beltrami, Antonio
Kobayashi, Kazuto
Gallo, Vittorio
Santoro, Claudio
Ferrer, Isidro (Ferrer Abizanda)
Rivella, Stefano
Beltrami, Carlo Alberto
Carninci, Piero
Raviola, Elio
Gustincich, Stefano
author_role author
author2 Pinto, Milena
Cesselli, Daniela
Zaninello, Marta
Lazarevic, Dejan
Roncaglia, Paola
Simone, Roberto
Vlachouli, Christina
Plessy, Charles
Bertin, Nicolas
Beltrami, Antonio
Kobayashi, Kazuto
Gallo, Vittorio
Santoro, Claudio
Ferrer, Isidro (Ferrer Abizanda)
Rivella, Stefano
Beltrami, Carlo Alberto
Carninci, Piero
Raviola, Elio
Gustincich, Stefano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuròglia
Metabolisme
Neurones
Citologia
Neuroglia
Metabolism
Neurons
Cytology
topic Neuròglia
Metabolisme
Neurones
Citologia
Neuroglia
Metabolism
Neurons
Cytology
description The mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the substantia nigra (SN) (A9 neurons) and the ventral tegmental area (VTA) (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Their selective degeneration leads to Parkinson's disease. Here, we report that gene expression analysis of A9 dopaminergic neurons (DA) identifies transcripts for alpha- and beta-chains of hemoglobin (Hb). Globin immunoreactivity decorates the majority of A9 DA, a subpopulation of cortical and hippocampal astrocytes and mature oligodendrocytes. This pattern of expression was confirmed in different mouse strains and in rat and human. We show that Hb is expressed in the SN of human postmortem brain. By microarray analysis of dopaminergic cell lines overexpressing alpha- and beta-globin chains, changes in genes involved in O(2) homeostasis and oxidative phopshorylation were observed, linking Hb expression to mitochondrial function. Our data suggest that the most famed oxygen-carrying globin is not exclusively restricted to the blood, but it may play a role in the normal physiology of the brain and neurodegenerative diseases.
publishDate 2009
dc.date.none.fl_str_mv 2009
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/141853
url https://hdl.handle.net/2445/141853
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1073/pnas.0813216106
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2009, vol. 106, num. 36, p. 15454-15459
https://doi.org/10.1073/pnas.0813216106
dc.rights.none.fl_str_mv (c) Biagioli, Marta et al., 2009
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Biagioli, Marta et al., 2009
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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