Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction

Epicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from...

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Autores: Grisales-Mejía, Juan Felipe, Álvarez-Rivera, Gerardo, Torres-Castañeda, Harlen G., Andrade-Mahecha, Margarita M., Martínez-Correa, Hugo A., Mendiola, J. A., Cifuentes, Alejandro, Ibáñez, Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/358870
Acceso en línea:http://hdl.handle.net/10261/358870
Access Level:acceso abierto
Palabra clave:Pressurized liquid extraction
Neuroprotective activity
Avocado by-products
Green extraction
Polyphenols
LC-QTOF-MS
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spelling Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extractionGrisales-Mejía, Juan FelipeÁlvarez-Rivera, GerardoTorres-Castañeda, Harlen G.Andrade-Mahecha, Margarita M.Martínez-Correa, Hugo A.Mendiola, J. A.Cifuentes, AlejandroIbáñez, ElenaPressurized liquid extractionNeuroprotective activityAvocado by-productsGreen extractionPolyphenolsLC-QTOF-MSEpicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from 100% epicarp with pure water (0% ethanol) at 40 °C and 100 bar, demonstrated high extraction yield (26.8 ± 0.9%) and total phenol content (TPC = 505 ± 25 mg gallic acid equivalent/g dry extract), good antioxidant capacity (ABTS = 3350 ± 179 µmol Trolox equivalent/g dry extract, ORAC = 0.14 ± 0.01 µg/mL), and moderate acetylcholinesterase inhibition (33.6 ± 2.9 µg/mL). UHPLC-ESI-QTOF-MS analysis of the optimal extracts tentatively identified phenolic acids, phenolic alcohol derivatives, and various flavonoids; namely flavonols. The results reveal the potential of avocado processing by-products, particularly the epicarp, as source of potential neuroprotective agents. The proposed PLE methodology was demonstrated to be a sustainable and efficient strategy for avocado residues valorization.This work has been funded by projects PID2020–113050RB-I00, PDC2021–120814-I00 and EQC2021–007112-P financed by Ministerio de Ciencia e Innovación (MICINN, Spanish Government); INCGLO0019 project financed by Spanish National Research Council (CSIC), and project 54892 financed by Universidad Nacional de Colombia. G.Á.-R. would like to acknowledge MICINN for a “Juan de la Cierva-Incorporación” postdoctoral grant IJC2019–041482-I.Peer reviewedElsevierMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas (España)Universidad Nacional de ColombiaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/358870reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113050RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-120814-I00info:eu-repo/grantAgreement/AEI//EQC2021-007112-Pinfo:eu-repo/grantAgreement/AEI//IJC2019–041482-IThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.supflu.2023.106117https://doi.org/10.1016/j.supflu.2023.106117Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3588702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
title Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
spellingShingle Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
Grisales-Mejía, Juan Felipe
Pressurized liquid extraction
Neuroprotective activity
Avocado by-products
Green extraction
Polyphenols
LC-QTOF-MS
title_short Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
title_full Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
title_fullStr Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
title_full_unstemmed Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
title_sort Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
dc.creator.none.fl_str_mv Grisales-Mejía, Juan Felipe
Álvarez-Rivera, Gerardo
Torres-Castañeda, Harlen G.
Andrade-Mahecha, Margarita M.
Martínez-Correa, Hugo A.
Mendiola, J. A.
Cifuentes, Alejandro
Ibáñez, Elena
author Grisales-Mejía, Juan Felipe
author_facet Grisales-Mejía, Juan Felipe
Álvarez-Rivera, Gerardo
Torres-Castañeda, Harlen G.
Andrade-Mahecha, Margarita M.
Martínez-Correa, Hugo A.
Mendiola, J. A.
Cifuentes, Alejandro
Ibáñez, Elena
author_role author
author2 Álvarez-Rivera, Gerardo
Torres-Castañeda, Harlen G.
Andrade-Mahecha, Margarita M.
Martínez-Correa, Hugo A.
Mendiola, J. A.
Cifuentes, Alejandro
Ibáñez, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas (España)
Universidad Nacional de Colombia
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Pressurized liquid extraction
Neuroprotective activity
Avocado by-products
Green extraction
Polyphenols
LC-QTOF-MS
topic Pressurized liquid extraction
Neuroprotective activity
Avocado by-products
Green extraction
Polyphenols
LC-QTOF-MS
description Epicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from 100% epicarp with pure water (0% ethanol) at 40 °C and 100 bar, demonstrated high extraction yield (26.8 ± 0.9%) and total phenol content (TPC = 505 ± 25 mg gallic acid equivalent/g dry extract), good antioxidant capacity (ABTS = 3350 ± 179 µmol Trolox equivalent/g dry extract, ORAC = 0.14 ± 0.01 µg/mL), and moderate acetylcholinesterase inhibition (33.6 ± 2.9 µg/mL). UHPLC-ESI-QTOF-MS analysis of the optimal extracts tentatively identified phenolic acids, phenolic alcohol derivatives, and various flavonoids; namely flavonols. The results reveal the potential of avocado processing by-products, particularly the epicarp, as source of potential neuroprotective agents. The proposed PLE methodology was demonstrated to be a sustainable and efficient strategy for avocado residues valorization.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/358870
url http://hdl.handle.net/10261/358870
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113050RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-120814-I00
info:eu-repo/grantAgreement/AEI//EQC2021-007112-P
info:eu-repo/grantAgreement/AEI//IJC2019–041482-I
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.supflu.2023.106117
https://doi.org/10.1016/j.supflu.2023.106117
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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