Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction
Epicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/358870 |
| Acceso en línea: | http://hdl.handle.net/10261/358870 |
| Access Level: | acceso abierto |
| Palabra clave: | Pressurized liquid extraction Neuroprotective activity Avocado by-products Green extraction Polyphenols LC-QTOF-MS |
| Sumario: | Epicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from 100% epicarp with pure water (0% ethanol) at 40 °C and 100 bar, demonstrated high extraction yield (26.8 ± 0.9%) and total phenol content (TPC = 505 ± 25 mg gallic acid equivalent/g dry extract), good antioxidant capacity (ABTS = 3350 ± 179 µmol Trolox equivalent/g dry extract, ORAC = 0.14 ± 0.01 µg/mL), and moderate acetylcholinesterase inhibition (33.6 ± 2.9 µg/mL). UHPLC-ESI-QTOF-MS analysis of the optimal extracts tentatively identified phenolic acids, phenolic alcohol derivatives, and various flavonoids; namely flavonols. The results reveal the potential of avocado processing by-products, particularly the epicarp, as source of potential neuroprotective agents. The proposed PLE methodology was demonstrated to be a sustainable and efficient strategy for avocado residues valorization. |
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