Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy

Biofabrication of three-dimensional (3D) cultures through the 3D Bioprinting technique opens new perspectives and applications of cell-laden hydrogels. However, to continue with the progress, new BioInks with specific properties must be carefully designed. In this study, we report the synthesis and...

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Detalles Bibliográficos
Autores: Molina, Brenda G., Fuentes Llanos, Judith, Alemán Llansó, Carlos, Sánchez Ordóñez, Samuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/209561
Acceso en línea:https://hdl.handle.net/2445/209561
Access Level:acceso abierto
Palabra clave:Impressió 3D
Teixits (Histologia)
Three-dimensional printing
Tissues
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spelling Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energyMolina, Brenda G.Fuentes Llanos, JudithAlemán Llansó, CarlosSánchez Ordóñez, SamuelImpressió 3DTeixits (Histologia)Three-dimensional printingTissuesBiofabrication of three-dimensional (3D) cultures through the 3D Bioprinting technique opens new perspectives and applications of cell-laden hydrogels. However, to continue with the progress, new BioInks with specific properties must be carefully designed. In this study, we report the synthesis and 3D Bioprinting of an electroconductive BioInk made of gelatin/fibrinogen hydrogel, C2C12 mouse myoblast and 5% w/w of conductive poly (3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs). The influence of PEDOT NPs, incorporated in the cellladen BioInk, not only showed a positive effect in cells viability, differentiation and myotube functionalities, also allowed the printed constructs to behaved as BioCapacitors. Such devices were able to electrochemically store a significant amount of energy (0.5 mF/cm2), enough to self-stimulate as BioActuator, with typical contractions ranging from 27 to 38 mu N, during nearly 50 min. The biofabrication of 3D constructs with the proposed electroconductive BioInk could lead to new devices for tissue engineering, biohybrid robotics or bioelectronics.Elsevier Ltd2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/209561Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.bios.2024.116117Biosensors & Bioelectronics, 2024, vol. 251https://doi.org/10.1016/j.bios.2024.116117cc by (c) Molina, Brenda G. et al, 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2095612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
title Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
spellingShingle Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
Molina, Brenda G.
Impressió 3D
Teixits (Histologia)
Three-dimensional printing
Tissues
title_short Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
title_full Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
title_fullStr Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
title_full_unstemmed Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
title_sort Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy
dc.creator.none.fl_str_mv Molina, Brenda G.
Fuentes Llanos, Judith
Alemán Llansó, Carlos
Sánchez Ordóñez, Samuel
author Molina, Brenda G.
author_facet Molina, Brenda G.
Fuentes Llanos, Judith
Alemán Llansó, Carlos
Sánchez Ordóñez, Samuel
author_role author
author2 Fuentes Llanos, Judith
Alemán Llansó, Carlos
Sánchez Ordóñez, Samuel
author2_role author
author
author
dc.subject.none.fl_str_mv Impressió 3D
Teixits (Histologia)
Three-dimensional printing
Tissues
topic Impressió 3D
Teixits (Histologia)
Three-dimensional printing
Tissues
description Biofabrication of three-dimensional (3D) cultures through the 3D Bioprinting technique opens new perspectives and applications of cell-laden hydrogels. However, to continue with the progress, new BioInks with specific properties must be carefully designed. In this study, we report the synthesis and 3D Bioprinting of an electroconductive BioInk made of gelatin/fibrinogen hydrogel, C2C12 mouse myoblast and 5% w/w of conductive poly (3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs). The influence of PEDOT NPs, incorporated in the cellladen BioInk, not only showed a positive effect in cells viability, differentiation and myotube functionalities, also allowed the printed constructs to behaved as BioCapacitors. Such devices were able to electrochemically store a significant amount of energy (0.5 mF/cm2), enough to self-stimulate as BioActuator, with typical contractions ranging from 27 to 38 mu N, during nearly 50 min. The biofabrication of 3D constructs with the proposed electroconductive BioInk could lead to new devices for tissue engineering, biohybrid robotics or bioelectronics.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/209561
url https://hdl.handle.net/2445/209561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.bios.2024.116117
Biosensors & Bioelectronics, 2024, vol. 251
https://doi.org/10.1016/j.bios.2024.116117
dc.rights.none.fl_str_mv cc by (c) Molina, Brenda G. et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Molina, Brenda G. et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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