Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders

The drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) and cocaine both increase the generation of free radicals, and in the case of MDMA, this increase in oxidative stress is involved in the dopaminergic neurotoxicity produced by the drug in mice. Oxidative stress processes are also...

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Detalhes bibliográficos
Autores: Peraile, Inés, Granado, Noelia, Torres, Elisa, Gutiérrez López, María Dolores, Moratalla, Rosario, Colado, Isabel, O’Shea, Esther
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Instituto Nacional de Técnica Aeroespacial (INTA)
Repositorio:DIGITAL.INTA Repositorio Digital del Instituto Nacional de Técnica Aeroespacial
OAI Identifier:oai:digital.inta.es:20.500.12666/1044
Acesso em linha:https://link.springer.com/article/10.1007/s00213-013-3142-5
http://hdl.handle.net/20.500.12666/1044
Access Level:acceso abierto
Palavra-chave:Oxidative stress
3,4-Methylenedioxymethamphetamine
Dopamine neurotoxicity
Cocaine
Descrição
Resumo:The drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) and cocaine both increase the generation of free radicals, and in the case of MDMA, this increase in oxidative stress is involved in the dopaminergic neurotoxicity produced by the drug in mice. Oxidative stress processes are also involved in the pathogenesis of several neurodegenerative diseases.

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