Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders
The drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) and cocaine both increase the generation of free radicals, and in the case of MDMA, this increase in oxidative stress is involved in the dopaminergic neurotoxicity produced by the drug in mice. Oxidative stress processes are also...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Instituto Nacional de Técnica Aeroespacial (INTA) |
| Repositorio: | DIGITAL.INTA Repositorio Digital del Instituto Nacional de Técnica Aeroespacial |
| OAI Identifier: | oai:digital.inta.es:20.500.12666/1044 |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00213-013-3142-5 http://hdl.handle.net/20.500.12666/1044 |
| Access Level: | acceso abierto |
| Palabra clave: | Oxidative stress 3,4-Methylenedioxymethamphetamine Dopamine neurotoxicity Cocaine |
| Sumario: | The drugs of abuse 3,4-methylenedioxymethamphetamine (MDMA; “ecstasy”) and cocaine both increase the generation of free radicals, and in the case of MDMA, this increase in oxidative stress is involved in the dopaminergic neurotoxicity produced by the drug in mice. Oxidative stress processes are also involved in the pathogenesis of several neurodegenerative diseases. |
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