Use of sevelamer in chronic kidney disease: Beyond phosphorus control

Sevelamer is a non-calcium phosphate binder used in advanced chronic kidney disease (CKD) and in dialysis for hyperphosphataemia control. Several experimental, observational studies and clinical trials have shown that sevelamer has pleiotropic effects, beyond hyperphosphataemia control, including ac...

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Detalles Bibliográficos
Autores: Rodríguez-Osorio, Laura, Pazmiño Zambrano, Diana, Gracia Iguacel, Carolina Marta, Rojas-Rivera, Jorge, Ortiz Arduán, Alberto, González Parra, Emilio José
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/672370
Acceso en línea:http://hdl.handle.net/10486/672370
https://dx.doi.org/10.1016/j.nefro.2015.05.022
Access Level:acceso abierto
Palabra clave:Sevelamer
Phosphate
Pleiotropic effects
Inflammation and gut
Medicina
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spelling Use of sevelamer in chronic kidney disease: Beyond phosphorus controlUso del sevelamer en la enfermedad renal crónica: Más allá del control del fósforoRodríguez-Osorio, LauraPazmiño Zambrano, DianaGracia Iguacel, Carolina MartaRojas-Rivera, JorgeOrtiz Arduán, AlbertoGonzález Parra, Emilio JoséSevelamerPhosphatePleiotropic effectsInflammation and gutMedicinaSevelamer is a non-calcium phosphate binder used in advanced chronic kidney disease (CKD) and in dialysis for hyperphosphataemia control. Several experimental, observational studies and clinical trials have shown that sevelamer has pleiotropic effects, beyond hyperphosphataemia control, including actions on inflammation, oxidative stress, lipid profile and atherogenesis, vascular calcification, endothelial dysfunction and the reduction of several uremic toxins. This is the biological basis for its global effect on cardiovascular morbidity and mortality in patients with chronic kidney disease. This review focuses on these pleiotropic actions of sevelamer and their impact on cardiovascular health, with the experience published after more than ten years of clinical expertiseEl sevelamer es un captor no cálcico de fósforo que se utiliza en la ERC avanzada y en diálisis para el control de la hiperfosforemia. Varios estudios experimentales, observacionales y ensayos clínicos han mostrado que el sevelamer tiene efectos pleiotrópicos, más allá del control de la hiperfosforemia, incluyendo acciones sobre la inflamación, el estrés oxidativo, el perfil lipídico y la aterogénesis, la calcificación vascular, la disfunción endotelial y la disminución de diversas toxinas urémicas, todo lo cual sería la base biológica de su efecto global sobre la morbilidad y la mortalidad cardiovascular en pacientes con enfermedad renal crónica. En esta revisión, se hace énfasis en estas acciones pleiotrópicas del sevelamer y su impacto en la salud cardiovascular, con la experiencia publicada después de más de 10 años de experiencia clínicaInstituto de Salud Carlos III [Carlos III Health Institute] (PI10/00072), REDINREN (Red de Investigación Renal [Renal Research Network]) (RD012/0021)Elsevier España SLUDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)20152015-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/672370https://dx.doi.org/10.1016/j.nefro.2015.05.022reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6723702026-06-23T12:46:27Z
dc.title.none.fl_str_mv Use of sevelamer in chronic kidney disease: Beyond phosphorus control
Uso del sevelamer en la enfermedad renal crónica: Más allá del control del fósforo
title Use of sevelamer in chronic kidney disease: Beyond phosphorus control
spellingShingle Use of sevelamer in chronic kidney disease: Beyond phosphorus control
Rodríguez-Osorio, Laura
Sevelamer
Phosphate
Pleiotropic effects
Inflammation and gut
Medicina
title_short Use of sevelamer in chronic kidney disease: Beyond phosphorus control
title_full Use of sevelamer in chronic kidney disease: Beyond phosphorus control
title_fullStr Use of sevelamer in chronic kidney disease: Beyond phosphorus control
title_full_unstemmed Use of sevelamer in chronic kidney disease: Beyond phosphorus control
title_sort Use of sevelamer in chronic kidney disease: Beyond phosphorus control
dc.creator.none.fl_str_mv Rodríguez-Osorio, Laura
Pazmiño Zambrano, Diana
Gracia Iguacel, Carolina Marta
Rojas-Rivera, Jorge
Ortiz Arduán, Alberto
González Parra, Emilio José
author Rodríguez-Osorio, Laura
author_facet Rodríguez-Osorio, Laura
Pazmiño Zambrano, Diana
Gracia Iguacel, Carolina Marta
Rojas-Rivera, Jorge
Ortiz Arduán, Alberto
González Parra, Emilio José
author_role author
author2 Pazmiño Zambrano, Diana
Gracia Iguacel, Carolina Marta
Rojas-Rivera, Jorge
Ortiz Arduán, Alberto
González Parra, Emilio José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
dc.subject.none.fl_str_mv Sevelamer
Phosphate
Pleiotropic effects
Inflammation and gut
Medicina
topic Sevelamer
Phosphate
Pleiotropic effects
Inflammation and gut
Medicina
description Sevelamer is a non-calcium phosphate binder used in advanced chronic kidney disease (CKD) and in dialysis for hyperphosphataemia control. Several experimental, observational studies and clinical trials have shown that sevelamer has pleiotropic effects, beyond hyperphosphataemia control, including actions on inflammation, oxidative stress, lipid profile and atherogenesis, vascular calcification, endothelial dysfunction and the reduction of several uremic toxins. This is the biological basis for its global effect on cardiovascular morbidity and mortality in patients with chronic kidney disease. This review focuses on these pleiotropic actions of sevelamer and their impact on cardiovascular health, with the experience published after more than ten years of clinical expertise
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/672370
https://dx.doi.org/10.1016/j.nefro.2015.05.022
url http://hdl.handle.net/10486/672370
https://dx.doi.org/10.1016/j.nefro.2015.05.022
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier España SLU
publisher.none.fl_str_mv Elsevier España SLU
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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