Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-erythritol2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli

In the bacterium Escherichiacoli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3H]methylerythritol 2,4-cyclodiphosphate. This...

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Detalhes bibliográficos
Autores: Seemann, Myriam, Campos Martínez, Narciso, Rodríguez Concepción, Manuel, Hoeffler, Jean François, Grosdemange Billiard, Catherine, Boronat i Margosa, Albert, Rohmer, Michel
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2002
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225922
Acesso em linha:https://hdl.handle.net/2445/225922
Access Level:acceso abierto
Palavra-chave:Metabolisme microbià
Escheríchia coli
Microbial metabolism
Escherichia coli
Descrição
Resumo:In the bacterium Escherichiacoli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3H]methylerythritol 2,4-cyclodiphosphate. This suggests that the GCPE protein is involved in the further conversion of methylerythritol cyclodiphosphate into isoprenoids.

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