Contribution to pathogenesis of accessory proteins of deadly human coronaviruses

Coronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes coding for structural proteins (S, M, N and E), and genes encoding accessory proteins, which are variable in number, sequence and func...

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Detalles Bibliográficos
Autores: Hurtado-Tamayo, Jesús, Requena-Platek, Ricardo, Enjuanes Sánchez, Luis, Bello-Perez, Melissa, Solá Gurpegui, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/362942
Acceso en línea:http://hdl.handle.net/10261/362942
https://api.elsevier.com/content/abstract/scopus_id/85159758914
Access Level:acceso abierto
Palabra clave:MERS-CoV
SARS-CoV
SARS-CoV-2
accessory proteins
coronavirus
innate immune response
pathogenesis
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spelling Contribution to pathogenesis of accessory proteins of deadly human coronavirusesHurtado-Tamayo, JesúsRequena-Platek, RicardoEnjuanes Sánchez, LuisBello-Perez, MelissaSolá Gurpegui, IsabelMERS-CoVSARS-CoVSARS-CoV-2accessory proteinscoronavirusinnate immune responsepathogenesisCoronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes coding for structural proteins (S, M, N and E), and genes encoding accessory proteins, which are variable in number, sequence and function among different CoVs. Accessory proteins are non-essential for virus replication, but are frequently involved in virus-host interactions associated with virulence. The scientific literature on CoV accessory proteins includes information analyzing the effect of deleting or mutating accessory genes in the context of viral infection, which requires the engineering of CoV genomes using reverse genetics systems. However, a considerable number of publications analyze gene function by overexpressing the protein in the absence of other viral proteins. This ectopic expression provides relevant information, although does not acknowledge the complex interplay of proteins during virus infection. A critical review of the literature may be helpful to interpret apparent discrepancies in the conclusions obtained by different experimental approaches. This review summarizes the current knowledge on human CoV accessory proteins, with an emphasis on their contribution to virus-host interactions and pathogenesis. This knowledge may help the search for antiviral drugs and vaccine development, still needed for some highly pathogenic human CoVs.This work was supported by grants from the Government of Spain (PID2019-107001RB-I00 AEI/FEDER, UE; SEV 2017-0712 and PIE_INTRAMURAL_Ref.-202020E079), the CSIC (PIE_INTRAMURAL-202020E043), the European Commission (ISOLDA_848166 H2020-SC1-2019; MANCO_101003651 H2020- SC1-PHE-CORONAVIRUS-2020), and the U.S. National Institutes of Health (NIH_2P01AI060699). JH-T received a fellowship from PID2019-107001RB-I00 AEI/FEDER, UE. RR-P received a fellowship from Arnhold de la Camara Foundation. MB-P received a contract from ISOLDA Project and a Jose Castillejo fellowship for PhDs mobility. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedFrontiers MediaAgencia Estatal de Investigación (España)European CommissionNational Institutes of Health (US)Enjuanes, Luis [0000-0002-0854-0226]Solá Gurpegui, Isabel [0000-0002-5704-1917]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/362942https://api.elsevier.com/content/abstract/scopus_id/85159758914reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107001RB-I00Frontiers in cellular and infection microbiologyapplication/pdfSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3629422026-05-22T06:33:51Z
dc.title.none.fl_str_mv Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
title Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
spellingShingle Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
Hurtado-Tamayo, Jesús
MERS-CoV
SARS-CoV
SARS-CoV-2
accessory proteins
coronavirus
innate immune response
pathogenesis
title_short Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
title_full Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
title_fullStr Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
title_full_unstemmed Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
title_sort Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
dc.creator.none.fl_str_mv Hurtado-Tamayo, Jesús
Requena-Platek, Ricardo
Enjuanes Sánchez, Luis
Bello-Perez, Melissa
Solá Gurpegui, Isabel
author Hurtado-Tamayo, Jesús
author_facet Hurtado-Tamayo, Jesús
Requena-Platek, Ricardo
Enjuanes Sánchez, Luis
Bello-Perez, Melissa
Solá Gurpegui, Isabel
author_role author
author2 Requena-Platek, Ricardo
Enjuanes Sánchez, Luis
Bello-Perez, Melissa
Solá Gurpegui, Isabel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
European Commission
National Institutes of Health (US)
Enjuanes, Luis [0000-0002-0854-0226]
Solá Gurpegui, Isabel [0000-0002-5704-1917]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv MERS-CoV
SARS-CoV
SARS-CoV-2
accessory proteins
coronavirus
innate immune response
pathogenesis
topic MERS-CoV
SARS-CoV
SARS-CoV-2
accessory proteins
coronavirus
innate immune response
pathogenesis
description Coronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes coding for structural proteins (S, M, N and E), and genes encoding accessory proteins, which are variable in number, sequence and function among different CoVs. Accessory proteins are non-essential for virus replication, but are frequently involved in virus-host interactions associated with virulence. The scientific literature on CoV accessory proteins includes information analyzing the effect of deleting or mutating accessory genes in the context of viral infection, which requires the engineering of CoV genomes using reverse genetics systems. However, a considerable number of publications analyze gene function by overexpressing the protein in the absence of other viral proteins. This ectopic expression provides relevant information, although does not acknowledge the complex interplay of proteins during virus infection. A critical review of the literature may be helpful to interpret apparent discrepancies in the conclusions obtained by different experimental approaches. This review summarizes the current knowledge on human CoV accessory proteins, with an emphasis on their contribution to virus-host interactions and pathogenesis. This knowledge may help the search for antiviral drugs and vaccine development, still needed for some highly pathogenic human CoVs.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/362942
https://api.elsevier.com/content/abstract/scopus_id/85159758914
url http://hdl.handle.net/10261/362942
https://api.elsevier.com/content/abstract/scopus_id/85159758914
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107001RB-I00
Frontiers in cellular and infection microbiology
application/pdf
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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