SARS-CoV-2 ORF8 accessory protein is a virulence factor

The relevance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 in the pathogenesis of COVID-19 is unclear. Virus natural isolates with deletions in ORF8 were associated with wild milder disease, suggesting that ORF8 might contribute to SARS-CoV-2 virulence. This manuscript shows...

ver descrição completa

Detalhes bibliográficos
Autores: Bello-Pérez, Melissa, Hurtado-Tamayo, Jesús, Mykytyn, Anna Z., Lamers, Mart M., Requena-Platek, Ricardo, Schipper, D., Muñoz-Santos, Diego, Ripoll-Gómez, Jorge, Esteban, Ana, Sánchez-Cordón, Pedro J., Enjuanes Sánchez, Luis, Haagmans, Bart L., Solá Gurpegui, Isabel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/360166
Acesso em linha:http://hdl.handle.net/10261/360166
https://api.elsevier.com/content/abstract/scopus_id/85176732230
Access Level:acceso abierto
Palavra-chave:SARS-CoV-2
Accessory proteins
Coronavirus
Viral pathogenesis
Virulence
Descrição
Resumo:The relevance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF8 in the pathogenesis of COVID-19 is unclear. Virus natural isolates with deletions in ORF8 were associated with wild milder disease, suggesting that ORF8 might contribute to SARS-CoV-2 virulence. This manuscript shows that ORF8 is involved in inflammation and in the activation of macrophages in two experimental systems: humanized K18-hACE2 transgenic mice and organoid-derived human airway cells. These results identify ORF8 protein as a potential target for COVID-19 therapies.

Registos relacionados