On interrogating electron microscopy images to discover proteins in the cell
Interrogating individual two-dimensional (2D) cryo-EM images for the presence of defined three-dimensional (3D) structures that correspond to previously known (or predicted) macromolecular complexes is very challenging, but offers attractive opportunities for the analysis of large numbers of specime...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/391071 |
| Acceso en línea: | http://hdl.handle.net/10261/391071 https://api.elsevier.com/content/abstract/scopus_id/86000669764 |
| Access Level: | acceso abierto |
| Palabra clave: | Cryo-EM Cryo-electron microscopy Image processing Protein structure Template matching |
| Sumario: | Interrogating individual two-dimensional (2D) cryo-EM images for the presence of defined three-dimensional (3D) structures that correspond to previously known (or predicted) macromolecular complexes is very challenging, but offers attractive opportunities for the analysis of large numbers of specimens. The work of Zhang et al. [(2025), IUCrJ, 12, 155-176] represents a significant step forward towards this goal. |
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