Risk factors of lung, head and neck, esophageal, and kidney and urinary tract carcinomas after liver transplantation: the effect of smoking withdrawal

Liver transplant recipients have an increased risk of malignancy. Smoking is related to some of the most frequent causes of posttransplant malignancy. The incidence and risk factors for the development of neoplasia related to smoking (head and neck, lung, esophageal, and kidney and urinary tract car...

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Detalles Bibliográficos
Autores: Herrero-Santos, J.I. (José Ignacio)|||/items/4df6083a-1ce6-4c19-a3fa-1b7d8bc58e1d, Pardo, F. (Fernando)|||/items/f4488eb3-3bf9-4dff-9d3f-402f36a1721e, D'Avola, D. (Delia)|||/items/c2bf1118-f768-493d-955c-d1ea525ed956, Alegre, F. (Félix)|||/items/522c5195-a7ad-446d-b207-92163af3caca, Rotellar-Sastre, F. (Fernando)|||/items/833cb788-f4b9-404d-a18b-ae1c84369b51, Iñarrairaegui-Bastarrica, M. (Mercedes)|||/items/c0e6fd5c-24cd-4a98-8b45-f4c895e7ccd6, Marti-Cruchaga, P. (Pablo)|||/items/97577c37-4c78-4a17-8b03-55eec0b40ff9, Sangro-Gómez-Acebo, B.C. (Bruno Carlos)|||/items/594bbdbb-046a-4ab2-878c-cb4fe577af49, Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/27544
Acceso en línea:https://hdl.handle.net/10171/27544
Access Level:acceso abierto
Palabra clave:Esophageal Neoplasms/etiology
Head and Neck Neoplasms/etiology
Kidney Neoplasms/etiology
Hepatología
Descripción
Sumario:Liver transplant recipients have an increased risk of malignancy. Smoking is related to some of the most frequent causes of posttransplant malignancy. The incidence and risk factors for the development of neoplasia related to smoking (head and neck, lung, esophageal, and kidney and urinary tract carcinomas) were studied in 339 liver transplant recipients. Risk factors for the development of smoking-related neoplasia were also studied in 135 patients who had a history of smoking so that it could be determined whether smoking withdrawal was associated with a lower risk of malignancy. After a mean follow-up of 7.5 years, 26 patients were diagnosed with 29 smoking-related malignancies. The 5- and 10-year actuarial rates were 5% and 13%, respectively. In multivariate analysis, smoking and older age were independently associated with a higher risk of malignancy. In the smoker subgroup, the variables related to a higher risk of malignancy were active smoking and older age. In conclusion, smoking withdrawal after liver transplantation may have a protective effect against the development of neoplasia.

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