Lifestyle-dependent microglial plasticity: training the brain guardians
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performanc...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/53137 |
| Acceso en línea: | http://hdl.handle.net/10810/53137 |
| Access Level: | acceso abierto |
| Palabra clave: | microglia neuroplasticity enriched environment physical exercise lifestyle modifications diet pluslong-term potentiation high-fat diet environmental enrichment physical-activity hippocampal neurogenesis adult neurogenesis voluntary exercise cognitive function improves memory dentate gyrus |
| Sumario: | Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity. |
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