Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of liver sinusoidal endothelial ce...

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Bibliographic Details
Authors: Ortega-Ribera, Martí, Gibert-Ramos, Albert, Abad-Jordà, Laia, Magaz, Marta, Téllez, Luis, Paule, Lorena, Castillo, Elisa, Pastó, Raül, de Souza Basso, Bruno, Olivas, Pol, Orts, Lara, Lozano, Juan José, Villa, Rosa, Bosch, Jaime, Albillos, Agustín, García-Pagán, Joan Carles, Gracia-Sancho, Jordi
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350107
Online Access:http://hdl.handle.net/10261/350107
https://api.elsevier.com/content/abstract/scopus_id/85153400368
Access Level:Open access
Keyword:Endothelial dysfunction
HCV
HVPG
Hepatic haemodynamic
LSEC
Liver cirrhosis
Liver sinusoidal endothelial cells
Mechanobiology
Mechanotransduction
NASH
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Summary:Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of liver sinusoidal endothelial cells (LSECs) during disease progression. The aim of this study was to investigate the effects of increased hydrodynamic pressure on LSECs and to identify endothelial-derived biomarkers of PH.

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