Insights into the adaptative history of African human populations from whole-genome sequence data
Africa is the origin source of modern humans. Despite that African populations harbor the highest levels of genetic diversity worldwide, they remain underrepresented in genetic studies. Therefore, in order to fully understand modern human evolutionary history it is fundamental to include more Africa...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/668469 |
| Acceso en línea: | http://hdl.handle.net/10803/668469 |
| Access Level: | acceso abierto |
| Palabra clave: | Natural selection Whole genome-sequencing Africa Population genetics Ethiopia Genetic adaptation TRPP3 Selecció natural Secuenciació genomes Genètica de poblacións 575 |
| Sumario: | Africa is the origin source of modern humans. Despite that African populations harbor the highest levels of genetic diversity worldwide, they remain underrepresented in genetic studies. Therefore, in order to fully understand modern human evolutionary history it is fundamental to include more African populations in genetic studies. The work in this thesis is a small contribution to the study of African evolutionary history. In particular we have focused on two different locations of Africa, eastern and southern Africa. We have tried to unravel candidates of positive (or adaptive) selection through the analysis of whole-genome sequences of five Ethiopian populations and one KhoeSan population. Moreover, we have tried to fill the gap between genotype and phenotype of a candidate of adaptive selection in an Ethiopian population. |
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