New insights into human migration, demography and adaptation of Indian and South Asian populations from genome analyses
Human genome project published their first human whole genome sequence on 2001 at the cost of billions of dollars. Since, the cost of sequencing is decreasing faster than Moore’s law. Now, we not only have sequenced thousands of modern humans’ whole genome, we also obtained whole genome sequences of...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/511362 |
| Acceso en línea: | http://hdl.handle.net/10803/511362 |
| Access Level: | acceso abierto |
| Palabra clave: | Population Genetics Evolution Whole Genome Sequence Natural Selection Homini Genética de poblaciones Evolución Secuenciación del genoma completo Selección natural Homínido 575 |
| Sumario: | Human genome project published their first human whole genome sequence on 2001 at the cost of billions of dollars. Since, the cost of sequencing is decreasing faster than Moore’s law. Now, we not only have sequenced thousands of modern humans’ whole genome, we also obtained whole genome sequences of extinct hominin and other ancient modern humans with relatively good quality. These sequences granted us some unexpected results: like how recently modern humans left Africa and populated around all over the world (which is called recent African origin model) while doing so how they have admixed with multiple hominin populations. Until now modern biology (unlike physics) always dominated by empirical results compared to theoretical concepts, which forces people to perceive biology as a descriptive science. As we are obtaining more and more data every day, it is now time to push our theoretical concepts before empirical results in biology. Here in this thesis, we provided deeper knowledge about ancestry of Indian, Asian and Pacific populations. We were also able to reveal an unknown hominin population existed even before it is sequenced. In addition to these, we demonstrated strong natural selection could change human morphology drastically in a short period. |
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