Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments

This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimerc...

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Autores: Fernández-Afonso, Yilian, Asín, Laura, Beola, Lilianne, Fratila, Raluca M., Gutiérrez, Lucía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/303941
Acceso en línea:http://hdl.handle.net/10261/303941
Access Level:acceso abierto
Palabra clave:Magnetic nanoparticles
Iron oxides
Degradation
Animal models
Magnetic hyperthermia
Photothermal therapies
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spelling Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatmentsFernández-Afonso, YilianAsín, LauraBeola, LilianneFratila, Raluca M.Gutiérrez, LucíaMagnetic nanoparticlesIron oxidesDegradationAnimal modelsMagnetic hyperthermiaPhotothermal therapiesThis work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation in a medium simulating lysosome conditions. The particles physicochemical properties (size, size distribution, and magnetic properties) have been followed over the degradation process along 24 days. It was found that DMSA-coated particles degraded much faster than PMAO-coated ones. In addition, their heating properties under both the exposure to an alternating magnetic field or a near infrared light have been tracked along this degradation processes, assessing how the changes in their physicochemical properties affect their heating capacity. Along the degradation procedure, a stronger decrease of the particles heating properties has been observed in the frame of magnetic hyperthermia measurements, in comparison with the photothermal ones. Finally, the PMAO-coated particles have been selected for a degradation study in vivo after intratumoral administration. Interestingly, although the number of particles decreases with time in the tissue, the size and size distribution of the particles do not change significantly over time. This work is especially relevant in the frame of the design of in vivo hyperthermia treatments using magnetic nanoparticles as it would provide fundamental clues regarding the need of repeated doses or the possible use of a single administration depending on the treatment duration.This work was funded by the Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) through the MACBETH project (PGC2018-096016-B-I00 to R.M.F. and L.G.). Funding was also received from the European Commission through the TBMED project (DT-NMBP-02-2018, ID: 814439 to R.M.F.). The authors also acknowledge support from Gobierno de Aragón and Fondos FEDER for funding the Bionanosurf (E15_17R) research group. MINECO and FSE/Agencia Estatal de Investigación are also acknowledged for the Ramón y Cajal subprogram grant RYC-2015-17640 to R.M.F. Y.F-A. would like to thank Santander-Universidad Zaragoza Fellowship program for her PhD position.Peer reviewedAmerican Chemical SocietyMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionGobierno de AragónMinisterio de Economía y Competitividad (España)Universidad de ZaragozaBanco SantanderConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/303941reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-096016-B-I00info:eu-repo/grantAgreement/EC/H2020/814439info:eu-repo/grantAgreement/MINECO//RYC-2015-17640ACS Applied Nano Materialshttps://doi.org/10.1021/acsanm.2c03220Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3039412026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
spellingShingle Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
Fernández-Afonso, Yilian
Magnetic nanoparticles
Iron oxides
Degradation
Animal models
Magnetic hyperthermia
Photothermal therapies
title_short Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_full Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_fullStr Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_full_unstemmed Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
title_sort Influence of magnetic nanoparticle degradation in the frame of magnetic hyperthermia and photothermal treatments
dc.creator.none.fl_str_mv Fernández-Afonso, Yilian
Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author Fernández-Afonso, Yilian
author_facet Fernández-Afonso, Yilian
Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author_role author
author2 Asín, Laura
Beola, Lilianne
Fratila, Raluca M.
Gutiérrez, Lucía
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Gobierno de Aragón
Ministerio de Economía y Competitividad (España)
Universidad de Zaragoza
Banco Santander
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Magnetic nanoparticles
Iron oxides
Degradation
Animal models
Magnetic hyperthermia
Photothermal therapies
topic Magnetic nanoparticles
Iron oxides
Degradation
Animal models
Magnetic hyperthermia
Photothermal therapies
description This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties in the frame of hyperthermia treatments. Iron oxide magnetic nanoparticles (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation in a medium simulating lysosome conditions. The particles physicochemical properties (size, size distribution, and magnetic properties) have been followed over the degradation process along 24 days. It was found that DMSA-coated particles degraded much faster than PMAO-coated ones. In addition, their heating properties under both the exposure to an alternating magnetic field or a near infrared light have been tracked along this degradation processes, assessing how the changes in their physicochemical properties affect their heating capacity. Along the degradation procedure, a stronger decrease of the particles heating properties has been observed in the frame of magnetic hyperthermia measurements, in comparison with the photothermal ones. Finally, the PMAO-coated particles have been selected for a degradation study in vivo after intratumoral administration. Interestingly, although the number of particles decreases with time in the tissue, the size and size distribution of the particles do not change significantly over time. This work is especially relevant in the frame of the design of in vivo hyperthermia treatments using magnetic nanoparticles as it would provide fundamental clues regarding the need of repeated doses or the possible use of a single administration depending on the treatment duration.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/303941
url http://hdl.handle.net/10261/303941
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-096016-B-I00
info:eu-repo/grantAgreement/EC/H2020/814439
info:eu-repo/grantAgreement/MINECO//RYC-2015-17640
ACS Applied Nano Materials
https://doi.org/10.1021/acsanm.2c03220
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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