Emergence of magnetic nanoparticles in photothermal and ferroptotic therapies
With their distinctive physicochemical features, nanoparticles have gained recognition as effective multifunctional tools for biomedical applications, with designs and compositions tailored for specific uses. Notably, magnetic nanoparticles stand out as first-in-class examples of multiple modalities...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/353246 |
| Acceso en línea: | http://hdl.handle.net/10261/353246 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85173009647&doi=10.1039%2fd3mh00831b&partnerID=40&md5=0c419b89927d7a23bdc30e5f2ee458cc |
| Access Level: | acceso abierto |
| Palabra clave: | Hyperthermia, Induced Iron Magnetite Nanoparticles Photochemotherapy Phototherapy Cell death Diseases Hyperthermia therapy Infrared devices Iron oxides Magnetic resonance imaging Medical applications Metal ions Nanomagnetics Oncology iron magnetite nanoparticle Anti-cancer agents Biomedical applications Contrast agent High-frequency magnetic field Iron-based Magnetic hyperthermia Multiple modalities Photo-thermal Photothermal therapy Physicochemical features chemistry photochemotherapy phototherapy procedures thermotherapy Nanostructured materials |
| Sumario: | With their distinctive physicochemical features, nanoparticles have gained recognition as effective multifunctional tools for biomedical applications, with designs and compositions tailored for specific uses. Notably, magnetic nanoparticles stand out as first-in-class examples of multiple modalities provided by the iron-based composition. They have long been exploited as contrast agents for magnetic resonance imaging (MRI) or as anti-cancer agents generating therapeutic hyperthermia through high-frequency magnetic field application, known as magnetic hyperthermia (MHT). This review focuses on two more recent applications in oncology using iron-based nanomaterials: photothermal therapy (PTT) and ferroptosis. In PTT, the iron oxide core responds to a near-infrared (NIR) excitation and generates heat in its surrounding area, rivaling the efficiency of plasmonic gold-standard nanoparticles. This opens up the possibility of a dual MHT + PTT approach using a single nanomaterial. Moreover, the iron composition of magnetic nanoparticles can be harnessed as a chemotherapeutic asset. Degradation in the intracellular environment triggers the release of iron ions, which can stimulate the production of reactive oxygen species (ROS) and induce cancer cell death through ferroptosis. Consequently, this review emphasizes these emerging physical and chemical approaches for anti-cancer therapy facilitated by magnetic nanoparticles, combining all-in-one functionalities. © 2023 The Royal Society of Chemistry. |
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