AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex

11 páginas, 2 figuras.

Detalhes bibliográficos
Autores: Sanz, Pascual, Rubio, Teresa, García-Gimeno, María Adelaida
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/113158
Acesso em linha:http://hdl.handle.net/10261/113158
Access Level:acceso abierto
Palavra-chave:AMPK
CBM
Phosphorylation
Myristoylation
Ubiquitination
Sumoylation
Activators
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spelling AMPKbeta subunits, more than just a scaffold in the formation of AMPK complexSanz, PascualRubio, TeresaGarcía-Gimeno, María AdelaidaAMPKCBMPhosphorylationMyristoylationUbiquitinationSumoylationActivators11 páginas, 2 figuras.AMP-activated protein kinase (AMPK) is a sensor of energy status composed of a catalytic subunit (AMPK), a scaffolding subunit (AMPK) and a regulatory subunit involved in nucleotide binding (AMPK). Activation of AMPK results in enhancement of catabolic processes and downregulation of anabolic pathways with the aim to equilibrate the energy status of the cell. The study of the regulation of the activity of the AMPK complex has been traditionally focused on modifications of AMPK and AMPK subunits by post-translational changes (i.e. phosphorylation of the catalytic subunit) and allosteric activation by AMP. In this review we summarize recent reports that indicate that AMPK subunits are also critical players in AMPK function, since they can regulate the phosphorylation status and activity of the AMPK complex. AMPK1- and AMPK2-containing complexes differ in their capacity to be activated by specific drugs (i.e., A769622, salicylate) and also by the ability to undergo post-translational modifications. This selective behavior opens the possibility to design specific drugs that activate AMPK complexes containing specific -isoformsThis work was supported by a grant from the Spanish Ministry of Education and Science (SAF2011-27442) and a grant from Generalitat Valenciana (Prometeo 2009/051). T.R. is supported by a JAE-predoctoral fellowship from the Spanish Research Council (CSIC).Peer reviewedWiley-VCHFederation of European Biochemical SocietiesConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/113158reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1111/febs.12364Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1131582026-05-22T06:33:51Z
dc.title.none.fl_str_mv AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
title AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
spellingShingle AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
Sanz, Pascual
AMPK
CBM
Phosphorylation
Myristoylation
Ubiquitination
Sumoylation
Activators
title_short AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
title_full AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
title_fullStr AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
title_full_unstemmed AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
title_sort AMPKbeta subunits, more than just a scaffold in the formation of AMPK complex
dc.creator.none.fl_str_mv Sanz, Pascual
Rubio, Teresa
García-Gimeno, María Adelaida
author Sanz, Pascual
author_facet Sanz, Pascual
Rubio, Teresa
García-Gimeno, María Adelaida
author_role author
author2 Rubio, Teresa
García-Gimeno, María Adelaida
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv AMPK
CBM
Phosphorylation
Myristoylation
Ubiquitination
Sumoylation
Activators
topic AMPK
CBM
Phosphorylation
Myristoylation
Ubiquitination
Sumoylation
Activators
description 11 páginas, 2 figuras.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/113158
url http://hdl.handle.net/10261/113158
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1111/febs.12364
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
Federation of European Biochemical Societies
publisher.none.fl_str_mv Wiley-VCH
Federation of European Biochemical Societies
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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