Epigenetic mechanisms and posttranslational Modifications in systemic lupus erythematosus

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their su...

ver descrição completa

Detalhes bibliográficos
Autores: Navarro Quiroz, Elkin, Chavez-Estrada, Valeria, Macias-Ochoa, Karime, Ayala-Navarro, María Fernanda, Flores-Aguilar, Aniyensy Sarai, Morales Navarrete, Francisco, de la Cruz Lopez, Fernando, GOMEZ ESCORCIA, LORENA, Musso, Carlos, Aroca Martínez, Gustavo, Gonzales Torres, Henry, Díaz Pérez, Anderson, Cadena Bonfanti, Andres Angélo, Sarmiento Gutiérrez, Joany, Meza, Jainy, Diaz Arroyo, Esperanza, Bello-Lemus, Yesit, Ahmad, Mostapha, Navarro Quiroz, Roberto
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:Colombia
Recursos:Corporación Universidad de la Costa
Repositorio:Repositorio REDICUC
Idioma:inglés
OAI Identifier:oai:repositorio.cuc.edu.co:11323/6084
Acesso em linha:https://hdl.handle.net/11323/6084
https://repositorio.cuc.edu.co/
Access Level:acceso abierto
Palavra-chave:Posttranslational modifications
Epigenetic mechanisms
Systemic lupus erythematosus
Ubiquitination
SUMOylation
Glycosylation
Hydroxylation
Phosphorylation
Sulfation
Acetylation
Descrição
Resumo:The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology.

Registos relacionados