In silico characterization of human prion-like proteins

Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species....

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Autores: Iglesias, Valentin|||0000-0002-6133-0869, Paladin, Lisanna, Juan Blanco, Teresa, Pallarès i Goitiz, Irantzu|||0000-0002-8205-2060, Aloy, Patrick|||0000-0002-3557-0236, Tosatto, Silvio|||0000-0003-4525-7793, Ventura, Salvador|||0000-0002-9652-6351
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:223543
Acesso em linha:https://ddd.uab.cat/record/223543
https://dx.doi.org/urn:doi:10.3389/fphys.2019.00314
Access Level:acceso abierto
Palavra-chave:Prion-like proteins
Disease
Protein-protein interaction
Protein aggregation
Amyloid
Bioinformatics
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spelling In silico characterization of human prion-like proteinsbeyond neurological diseasesIglesias, Valentin|||0000-0002-6133-0869Paladin, LisannaJuan Blanco, TeresaPallarès i Goitiz, Irantzu|||0000-0002-8205-2060Aloy, Patrick|||0000-0002-3557-0236Tosatto, Silvio|||0000-0003-4525-7793Ventura, Salvador|||0000-0002-9652-6351Prion-like proteinsDiseaseProtein-protein interactionProtein aggregationAmyloidBioinformaticsPrion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species. Here, we perform a stringent computational survey to identify prion-like proteins in the human proteome. We detected 242 candidate polypeptides and computationally assessed their function, protein-protein interaction networks, tissular expression, and their link to disease. Human prion-like proteins constitute a subset of modular polypeptides broadly expressed across different cell types and tissues, significantly associated with disease, embedded in highly connected interaction networks, and involved in the flow of genetic information in the cell. Our analysis suggests that these proteins might play a relevant role not only in neurological disorders, but also in different types of cancer and viral infections. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/223543https://dx.doi.org/urn:doi:10.3389/fphys.2019.00314reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 614944Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2016-78310-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2016-77038-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2235432026-06-06T12:50:31Z
dc.title.none.fl_str_mv In silico characterization of human prion-like proteins
beyond neurological diseases
title In silico characterization of human prion-like proteins
spellingShingle In silico characterization of human prion-like proteins
Iglesias, Valentin|||0000-0002-6133-0869
Prion-like proteins
Disease
Protein-protein interaction
Protein aggregation
Amyloid
Bioinformatics
title_short In silico characterization of human prion-like proteins
title_full In silico characterization of human prion-like proteins
title_fullStr In silico characterization of human prion-like proteins
title_full_unstemmed In silico characterization of human prion-like proteins
title_sort In silico characterization of human prion-like proteins
dc.creator.none.fl_str_mv Iglesias, Valentin|||0000-0002-6133-0869
Paladin, Lisanna
Juan Blanco, Teresa
Pallarès i Goitiz, Irantzu|||0000-0002-8205-2060
Aloy, Patrick|||0000-0002-3557-0236
Tosatto, Silvio|||0000-0003-4525-7793
Ventura, Salvador|||0000-0002-9652-6351
author Iglesias, Valentin|||0000-0002-6133-0869
author_facet Iglesias, Valentin|||0000-0002-6133-0869
Paladin, Lisanna
Juan Blanco, Teresa
Pallarès i Goitiz, Irantzu|||0000-0002-8205-2060
Aloy, Patrick|||0000-0002-3557-0236
Tosatto, Silvio|||0000-0003-4525-7793
Ventura, Salvador|||0000-0002-9652-6351
author_role author
author2 Paladin, Lisanna
Juan Blanco, Teresa
Pallarès i Goitiz, Irantzu|||0000-0002-8205-2060
Aloy, Patrick|||0000-0002-3557-0236
Tosatto, Silvio|||0000-0003-4525-7793
Ventura, Salvador|||0000-0002-9652-6351
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Prion-like proteins
Disease
Protein-protein interaction
Protein aggregation
Amyloid
Bioinformatics
topic Prion-like proteins
Disease
Protein-protein interaction
Protein aggregation
Amyloid
Bioinformatics
description Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species. Here, we perform a stringent computational survey to identify prion-like proteins in the human proteome. We detected 242 candidate polypeptides and computationally assessed their function, protein-protein interaction networks, tissular expression, and their link to disease. Human prion-like proteins constitute a subset of modular polypeptides broadly expressed across different cell types and tissues, significantly associated with disease, embedded in highly connected interaction networks, and involved in the flow of genetic information in the cell. Our analysis suggests that these proteins might play a relevant role not only in neurological disorders, but also in different types of cancer and viral infections.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/223543
https://dx.doi.org/urn:doi:10.3389/fphys.2019.00314
url https://ddd.uab.cat/record/223543
https://dx.doi.org/urn:doi:10.3389/fphys.2019.00314
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 614944
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2016-78310-R
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2016-77038-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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