Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis

Brain lesions in patients with multiple sclerosis may lead to abnormal excitability of brainstem reflex circuits because of impairment of descending control pathways. We hypothesized that such abnormality should show in the analysis of blink reflex responses in the form of asymmetries in response si...

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Authors: Cabib, Christopher, Llufriu Duran, Sara, Martinez-Heras, Eloy, Saiz Hinarejos, Albert, Valls Solé, Josep
Format: article
Status:Published version
Publication Date:2014
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/149518
Online Access:https://hdl.handle.net/2445/149518
Access Level:Open access
Keyword:Esclerosi múltiple
Neurofisiologia
Multiple sclerosis
Neurophysiology
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spelling Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple SclerosisCabib, ChristopherLlufriu Duran, SaraMartinez-Heras, EloySaiz Hinarejos, AlbertValls Solé, JosepEsclerosi múltipleNeurofisiologiaMultiple sclerosisNeurophysiologyBrain lesions in patients with multiple sclerosis may lead to abnormal excitability of brainstem reflex circuits because of impairment of descending control pathways. We hypothesized that such abnormality should show in the analysis of blink reflex responses in the form of asymmetries in response size. The study was done in 20 patients with relapsing-remitting multiple sclerosis and 12 matched healthy subjects. We identified first patients with latency abnormalities (AbLat). Then, we analyzed response size by calculating the R2c/R2 ratio to stimulation of either side and the mean area of the R2 responses obtained in the same side. Patients with significantly larger response size with respect to healthy subjects in at least one side were considered to have abnormal response excitability (AbEx). We also examined the blink reflex excitability recovery (BRER) and prepulse inhibition (BRIP) of either side in search for additional indices of asymmetry in response excitability. Neurophysiological data were correlated with MRI-determined brain lesion-load and volume. Eight patients were identified as AbLat (median Expanded Disability Status Scale-EDSS = 2.75) and 7 of them had ponto-medullary lesions. Nine patients were identified as AbEx (EDSS = 1.5) and only 2 of them, who also were AbLat, had ponto-medullary lesions. In AbEx patients, the abnormalities in response size were confined to one side, with a similar tendency in most variables (significantly asymmetric R1 amplitude, BRER index and BRIP percentage). AbEx patients had asymmetric distribution of hemispheral lesions, in contrast with the symmetric pattern observed in AbLat. The brainstem lesion load was significantly lower in AbEx than in AbLat patients (p = 0.04). Asymmetric abnormalities in blink reflex response excitability in patients with multiple sclerosis are associated with lesser disability and lower tissue loss than abnormalities in response latency. Testing response excitability could provide a reliable neurophysiological index of dysfunction in early stages of multiple sclerosis.Public Library of Science (PLoS)2020202020142020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/149518Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0103897PLoS One, 2014, vol. 9, num. 8, p. e103897https://doi.org/10.1371/journal.pone.0103897cc-by (c) Cabib, Christopher et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1495182026-05-29T05:05:01Z
dc.title.none.fl_str_mv Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
title Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
spellingShingle Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
Cabib, Christopher
Esclerosi múltiple
Neurofisiologia
Multiple sclerosis
Neurophysiology
title_short Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
title_full Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
title_fullStr Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
title_full_unstemmed Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
title_sort Abnormal Control of Orbicularis Oculi Reflex Excitability in Multiple Sclerosis
dc.creator.none.fl_str_mv Cabib, Christopher
Llufriu Duran, Sara
Martinez-Heras, Eloy
Saiz Hinarejos, Albert
Valls Solé, Josep
author Cabib, Christopher
author_facet Cabib, Christopher
Llufriu Duran, Sara
Martinez-Heras, Eloy
Saiz Hinarejos, Albert
Valls Solé, Josep
author_role author
author2 Llufriu Duran, Sara
Martinez-Heras, Eloy
Saiz Hinarejos, Albert
Valls Solé, Josep
author2_role author
author
author
author
dc.subject.none.fl_str_mv Esclerosi múltiple
Neurofisiologia
Multiple sclerosis
Neurophysiology
topic Esclerosi múltiple
Neurofisiologia
Multiple sclerosis
Neurophysiology
description Brain lesions in patients with multiple sclerosis may lead to abnormal excitability of brainstem reflex circuits because of impairment of descending control pathways. We hypothesized that such abnormality should show in the analysis of blink reflex responses in the form of asymmetries in response size. The study was done in 20 patients with relapsing-remitting multiple sclerosis and 12 matched healthy subjects. We identified first patients with latency abnormalities (AbLat). Then, we analyzed response size by calculating the R2c/R2 ratio to stimulation of either side and the mean area of the R2 responses obtained in the same side. Patients with significantly larger response size with respect to healthy subjects in at least one side were considered to have abnormal response excitability (AbEx). We also examined the blink reflex excitability recovery (BRER) and prepulse inhibition (BRIP) of either side in search for additional indices of asymmetry in response excitability. Neurophysiological data were correlated with MRI-determined brain lesion-load and volume. Eight patients were identified as AbLat (median Expanded Disability Status Scale-EDSS = 2.75) and 7 of them had ponto-medullary lesions. Nine patients were identified as AbEx (EDSS = 1.5) and only 2 of them, who also were AbLat, had ponto-medullary lesions. In AbEx patients, the abnormalities in response size were confined to one side, with a similar tendency in most variables (significantly asymmetric R1 amplitude, BRER index and BRIP percentage). AbEx patients had asymmetric distribution of hemispheral lesions, in contrast with the symmetric pattern observed in AbLat. The brainstem lesion load was significantly lower in AbEx than in AbLat patients (p = 0.04). Asymmetric abnormalities in blink reflex response excitability in patients with multiple sclerosis are associated with lesser disability and lower tissue loss than abnormalities in response latency. Testing response excitability could provide a reliable neurophysiological index of dysfunction in early stages of multiple sclerosis.
publishDate 2014
dc.date.none.fl_str_mv 2014
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/149518
url https://hdl.handle.net/2445/149518
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0103897
PLoS One, 2014, vol. 9, num. 8, p. e103897
https://doi.org/10.1371/journal.pone.0103897
dc.rights.none.fl_str_mv cc-by (c) Cabib, Christopher et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cabib, Christopher et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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