Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition

Porcine circovirus 3 (PCV-3) was discovered in 2015 using next-generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical-pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evi...

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Autores: Saporiti, Viviane|||0000-0002-3787-2799, Franzo, Giovanni|||0000-0003-2991-217X, Sibila, Marina|||0000-0003-3867-1988, Segalés Coma, Joaquim|||0000-0002-1539-7261
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:266208
Acceso en línea:https://ddd.uab.cat/record/266208
https://dx.doi.org/urn:doi:10.1111/tbed.14204
Access Level:acceso abierto
Palabra clave:Case definition
Disease causality
Porcine circovirus 3 (PCV-3)
Reproductive disease
Systemic disease
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spelling Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definitionSaporiti, Viviane|||0000-0002-3787-2799Franzo, Giovanni|||0000-0003-2991-217XSibila, Marina|||0000-0003-3867-1988Segalés Coma, Joaquim|||0000-0002-1539-7261Case definitionDisease causalityPorcine circovirus 3 (PCV-3)Reproductive diseaseSystemic diseasePorcine circovirus 3 (PCV-3) was discovered in 2015 using next-generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical-pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evidence existing so far regarding PCV-3 as a swine pathogen. In fact, a significant number of publications claim PCV-3 as a disease causal infectious agent, but very few of them have shown strong evidence of such potential causality. The most convincing proofs of disease association are those that demonstrate a clinical picture linked to multisystemic lymphoplasmacytic to lymphohistiocytic perivascular inflammation and presence of viral nucleic acid within these lesions. Based on these evidence, individual case definitions for PCV-3-reproductive disease and PCV-3-systemic disease are proposed to standardize diagnostic criteria for PCV-3-associated diseases. However, the real frequency of these clinical-pathological conditions linked to the novel virus is unknown, and the most frequent outcome of PCV-3 infection is likely subclinical based on its worlwide distribution. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/266208https://dx.doi.org/urn:doi:10.1111/tbed.14204reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2662082026-06-06T12:50:31Z
dc.title.none.fl_str_mv Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
title Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
spellingShingle Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
Saporiti, Viviane|||0000-0002-3787-2799
Case definition
Disease causality
Porcine circovirus 3 (PCV-3)
Reproductive disease
Systemic disease
title_short Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
title_full Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
title_fullStr Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
title_full_unstemmed Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
title_sort Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition
dc.creator.none.fl_str_mv Saporiti, Viviane|||0000-0002-3787-2799
Franzo, Giovanni|||0000-0003-2991-217X
Sibila, Marina|||0000-0003-3867-1988
Segalés Coma, Joaquim|||0000-0002-1539-7261
author Saporiti, Viviane|||0000-0002-3787-2799
author_facet Saporiti, Viviane|||0000-0002-3787-2799
Franzo, Giovanni|||0000-0003-2991-217X
Sibila, Marina|||0000-0003-3867-1988
Segalés Coma, Joaquim|||0000-0002-1539-7261
author_role author
author2 Franzo, Giovanni|||0000-0003-2991-217X
Sibila, Marina|||0000-0003-3867-1988
Segalés Coma, Joaquim|||0000-0002-1539-7261
author2_role author
author
author
dc.subject.none.fl_str_mv Case definition
Disease causality
Porcine circovirus 3 (PCV-3)
Reproductive disease
Systemic disease
topic Case definition
Disease causality
Porcine circovirus 3 (PCV-3)
Reproductive disease
Systemic disease
description Porcine circovirus 3 (PCV-3) was discovered in 2015 using next-generation sequencing (NGS) methods. Since then, the virus has been detected worldwide in pigs displaying several clinical-pathological outcomes as well as in healthy animals. The objective of this review is to critically discuss the evidence existing so far regarding PCV-3 as a swine pathogen. In fact, a significant number of publications claim PCV-3 as a disease causal infectious agent, but very few of them have shown strong evidence of such potential causality. The most convincing proofs of disease association are those that demonstrate a clinical picture linked to multisystemic lymphoplasmacytic to lymphohistiocytic perivascular inflammation and presence of viral nucleic acid within these lesions. Based on these evidence, individual case definitions for PCV-3-reproductive disease and PCV-3-systemic disease are proposed to standardize diagnostic criteria for PCV-3-associated diseases. However, the real frequency of these clinical-pathological conditions linked to the novel virus is unknown, and the most frequent outcome of PCV-3 infection is likely subclinical based on its worlwide distribution.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/266208
https://dx.doi.org/urn:doi:10.1111/tbed.14204
url https://ddd.uab.cat/record/266208
https://dx.doi.org/urn:doi:10.1111/tbed.14204
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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