Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a ste...

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Autores: Bousquet, Jean, Antó i Boqué, Josep Maria, Sunyer Deu, Jordi, Melén, Erik, Benet, Marta, Basagaña Flores, Xavier, Torrent Quetglas, Maties, Xu, Cheng-Jian
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/28321
Acceso en línea:http://hdl.handle.net/10230/28321
http://dx.doi.org/10.1111/all.12880
Access Level:acceso abierto
Palabra clave:Asthma
IgE
Multimorbidity
Polysensitization
Rhinitis
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spelling Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success storyBousquet, JeanAntó i Boqué, Josep MariaSunyer Deu, JordiMelén, ErikBenet, MartaBasagaña Flores, XavierTorrent Quetglas, MatiesXu, Cheng-JianAsthmaIgEMultimorbidityPolysensitizationRhinitisMeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.Mechanisms of the Development of ALL ergy; EU FP 7‐CP ‐IP ; Project No: 261357; 2010–2015Wiley201720172016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/28321http://dx.doi.org/10.1111/all.12880reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAllergy. 2016;71(11):1513-25info:eu-repo/grantAgreement/EC/FP7/261357© 2016 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/283212026-06-12T07:21:37Z
dc.title.none.fl_str_mv Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
title Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
spellingShingle Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
Bousquet, Jean
Asthma
IgE
Multimorbidity
Polysensitization
Rhinitis
title_short Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
title_full Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
title_fullStr Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
title_full_unstemmed Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
title_sort Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
dc.creator.none.fl_str_mv Bousquet, Jean
Antó i Boqué, Josep Maria
Sunyer Deu, Jordi
Melén, Erik
Benet, Marta
Basagaña Flores, Xavier
Torrent Quetglas, Maties
Xu, Cheng-Jian
author Bousquet, Jean
author_facet Bousquet, Jean
Antó i Boqué, Josep Maria
Sunyer Deu, Jordi
Melén, Erik
Benet, Marta
Basagaña Flores, Xavier
Torrent Quetglas, Maties
Xu, Cheng-Jian
author_role author
author2 Antó i Boqué, Josep Maria
Sunyer Deu, Jordi
Melén, Erik
Benet, Marta
Basagaña Flores, Xavier
Torrent Quetglas, Maties
Xu, Cheng-Jian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asthma
IgE
Multimorbidity
Polysensitization
Rhinitis
topic Asthma
IgE
Multimorbidity
Polysensitization
Rhinitis
description MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/28321
http://dx.doi.org/10.1111/all.12880
url http://hdl.handle.net/10230/28321
http://dx.doi.org/10.1111/all.12880
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Allergy. 2016;71(11):1513-25
info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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