Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a ste...

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Authors: Bousquet, J, Anto, JM, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, DS, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, Tari, Lambrecht, BN, Lodrup Carlsen, KC, Koppelman, G. H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, Francesco, Heinrich, Joachim, Kowalski, ML, Maier, D, Melen, E, Palkonen, S, Smit, HA, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, KH, Chatzi, L, Coquet, JM, Curin, M, Demoly, P, Eller, E, Fantini, Maria Pia, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Makela, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Ranciere, F, Rial-Sebbag, A, Saeys, Y, Schuijs, MJ, Siroux, V, Tischer, CG, Torrent Quetglas, Maties, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C
Format: article
Publication Date:2016
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20232
Online Access:http://hdl.handle.net/20.500.12105/20232
Access Level:Open access
Keyword:Asthma
IgE
Multimorbidity
Polysensitization
Rhinitis
Manejo de la Enfermedad
Política de Salud
Hipersensibilidad
Inmunización
Biología de Sistemas
Humanos
Pronóstico
Unión Europea
Organización Mundial de la Salud
Medicina de Precisión
Inmunoglobulina E
Invenciones
Prognosis
World Health Organization
Precision Medicine
European Union
Health Policy
Hypersensitivity
Immunoglobulin E
Humans
Inventions
Systems Biology
Disease Management
Immunization
Description
Summary:MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

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