Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease

Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross...

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Autores: Santos García, Diego, Puente Periz, Victor Manuel, COPPADIS Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59927
Acceso en línea:http://hdl.handle.net/10230/59927
http://dx.doi.org/10.3390/jcm12041329
Access Level:acceso abierto
Palabra clave:Motor
Non-motor symptoms
Gender
Parkinson’s disease
Quality of life
Sex
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spelling Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's diseaseSantos García, DiegoPuente Periz, Victor ManuelCOPPADIS Study GroupMotorNon-motor symptomsGenderParkinson’s diseaseQuality of lifeSexBackground and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.MDPI202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59927http://dx.doi.org/10.3390/jcm12041329reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJ Clin Med. 2023 Feb 7;12(4):1329© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/599272026-06-12T07:21:37Z
dc.title.none.fl_str_mv Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
title Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
spellingShingle Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
Santos García, Diego
Motor
Non-motor symptoms
Gender
Parkinson’s disease
Quality of life
Sex
title_short Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
title_full Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
title_fullStr Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
title_full_unstemmed Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
title_sort Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
dc.creator.none.fl_str_mv Santos García, Diego
Puente Periz, Victor Manuel
COPPADIS Study Group
author Santos García, Diego
author_facet Santos García, Diego
Puente Periz, Victor Manuel
COPPADIS Study Group
author_role author
author2 Puente Periz, Victor Manuel
COPPADIS Study Group
author2_role author
author
dc.subject.none.fl_str_mv Motor
Non-motor symptoms
Gender
Parkinson’s disease
Quality of life
Sex
topic Motor
Non-motor symptoms
Gender
Parkinson’s disease
Quality of life
Sex
description Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59927
http://dx.doi.org/10.3390/jcm12041329
url http://hdl.handle.net/10230/59927
http://dx.doi.org/10.3390/jcm12041329
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv J Clin Med. 2023 Feb 7;12(4):1329
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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