Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease

Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysi...

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Autores: Santos García, Diego|||0000-0002-3126-5111, Laguna, Ariadna|||0000-0002-9732-6677, Hernández-Vara, Jorge|||0000-0002-9129-5224, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos|||0000-0002-8352-2263, Feal Painceiras, Maria J., Íñiguez Alvarado, María Cristina, García Díaz, Iago|||0000-0003-3304-0714, Jesús, Silvia, Boungiorno, M. T., Planellas, Lluis|||0000-0002-0769-6675, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria|||0000-0003-3363-3077, Legarda, Inés, Cabo-Lopez, Iria|||0000-0003-2436-6499, López Manzanares, Lydia|||0000-0003-4615-4542, Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093, Ávila Rivera, Maria A., Gómez Mayordomo, Víctor|||0000-0001-9343-8439, Nogueira, Víctor, Puente, Víctor, Dotor García-Soto, Julio, Borrué, Carmen, Solano Vila, Berta|||0009-0007-8945-0487, Álvarez Sauco, María, Vela, Lydia|||0000-0001-6663-395X, Escalante, Sonia|||0000-0001-8931-1400, Cubo, Esther|||0000-0003-0018-1182, Carrillo Padilla, Francisco, Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850, Sánchez Alonso, Pilar|||0000-0003-0496-4707, Alonso Losada, Maria G., López Ariztegui, Nuria|||0000-0001-7172-3191, Gastón, Itziar, Kulisevsky, Jaime|||0000-0003-4870-1431, Mendez-Gonzalez, Manuel|||0000-0002-5218-0774, Seijo, Manuel, Rúiz Martínez, Javier, Valero, Caridad, Kurtis, Mónica|||0000-0003-3037-9712, González Ardura, Jessica, Alonso Redondo, Ruben, Ordás Bandera, Carlos Manuel|||0000-0003-3551-8769, López Díaz, Luis M., McAfee, Darrian, Martinez-Martin, Pablo|||0000-0003-0837-5280, Mir, Pablo|||0000-0003-1656-302X
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:302820
Acesso em linha:https://ddd.uab.cat/record/302820
https://dx.doi.org/urn:doi:10.3390/jcm12041329
Access Level:acceso abierto
Palavra-chave:Gender
Motor
Non-motor symptoms
Parkinson's disease
Quality of life
Sex
Descrição
Resumo:Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.

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