Surface treatment of titanium with antibacterial properties for biomedical applications

Titanium and its derivative alloys are attracting increasing interest in the medical field due to the many advantages it appears to possess. Indeed, titanium is widely used as a biomaterial for implants and prostheses in the fields of orthodontics and orthopaedics, thanks to its high biocompatibilit...

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Detalhes bibliográficos
Autor: Aydogan, Victor
Formato: tesis de maestría
Fecha de publicación:2023
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/386221
Acesso em linha:https://hdl.handle.net/2117/386221
Access Level:acceso abierto
Palavra-chave:Titanium -- Medical applications
Titanium
surface treatment
nanotubes
biomedical
Titani -- Aplicacions mèdiques
Àrees temàtiques de la UPC::Enginyeria dels materials
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oai_identifier_str oai:upcommons.upc.edu:2117/386221
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Surface treatment of titanium with antibacterial properties for biomedical applications
title Surface treatment of titanium with antibacterial properties for biomedical applications
spellingShingle Surface treatment of titanium with antibacterial properties for biomedical applications
Aydogan, Victor
Titanium -- Medical applications
Titanium
surface treatment
nanotubes
biomedical
Titani -- Aplicacions mèdiques
Àrees temàtiques de la UPC::Enginyeria dels materials
title_short Surface treatment of titanium with antibacterial properties for biomedical applications
title_full Surface treatment of titanium with antibacterial properties for biomedical applications
title_fullStr Surface treatment of titanium with antibacterial properties for biomedical applications
title_full_unstemmed Surface treatment of titanium with antibacterial properties for biomedical applications
title_sort Surface treatment of titanium with antibacterial properties for biomedical applications
dc.creator.none.fl_str_mv Aydogan, Victor
author Aydogan, Victor
author_facet Aydogan, Victor
author_role author
dc.contributor.none.fl_str_mv Rodríguez Rius, Daniel
dc.subject.none.fl_str_mv Titanium -- Medical applications
Titanium
surface treatment
nanotubes
biomedical
Titani -- Aplicacions mèdiques
Àrees temàtiques de la UPC::Enginyeria dels materials
topic Titanium -- Medical applications
Titanium
surface treatment
nanotubes
biomedical
Titani -- Aplicacions mèdiques
Àrees temàtiques de la UPC::Enginyeria dels materials
description Titanium and its derivative alloys are attracting increasing interest in the medical field due to the many advantages it appears to possess. Indeed, titanium is widely used as a biomaterial for implants and prostheses in the fields of orthodontics and orthopaedics, thanks to its high biocompatibility regarding low ion release. Titanium also has outstanding corrosion resistance, great mechanical properties in terms of high hardness, low modulus of elasticity, low density, and high fatigue limit, which is a requirement for most implants. The above-mentioned remarkable biocompatibility of titanium is related to the development of a native oxide layer on its surface when exposed to air. In addition, this layer can develop in certain arranged patterns, that prove to be useful for the local administration of antibacterial agents, thus offering an alternative to aggressive surgical procedures against implant-related infections. Indeed, the main causes of implant failure are prosthesis-related infections. Thus, the aim of this project is to prevent infection of titanium implants when embedded in the body by loading the titanium oxide layer with an antibacterial agent and to develop coatings to reach release close to the zero kinetic order. For this purpose, a specific titanium dioxide structure, titanium nanotubes, was developed using an electrochemical oxidation reaction, and studied by looking at the different parameters affecting their geometry. The nanotubes were then loaded with an antibacterial agent and coated with two different coatings. These coatings are intended to degrade gradually to allow the antibacterial agent to be released with a steady flow without causing an overdose and thus prevent the growth of bacterial biofilms. Titanium nanotubes samples were characterized using a Scanning Electron Microscope (SEM) allowing to see the influence of the growing parameters. Coatings were characterized using Fourier-Transform Infrared Spectroscopy (FTIR). Various bacteriological studies were carried to see the impact of the different parameters, including surface geometries and types of coatings. The results were analyzed and showed successful growth of nanotubes capable of storing a bactericidal agent. In addition, the coatings were developed with great success. Bacterial studies showed a great antibacterial effect of the coatings or antibacterial loaded nanotube samples. However, the aspect of zero-order diffusion will not have been addressed in this project.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-10
2023
2023-04-14
dc.type.none.fl_str_mv master thesis
http://purl.org/coar/resource_type/c_bdcc
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/386221
url https://hdl.handle.net/2117/386221
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat Politècnica de Catalunya
publisher.none.fl_str_mv Universitat Politècnica de Catalunya
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Surface treatment of titanium with antibacterial properties for biomedical applicationsAydogan, VictorTitanium -- Medical applicationsTitaniumsurface treatmentnanotubesbiomedicalTitani -- Aplicacions mèdiquesÀrees temàtiques de la UPC::Enginyeria dels materialsTitanium and its derivative alloys are attracting increasing interest in the medical field due to the many advantages it appears to possess. Indeed, titanium is widely used as a biomaterial for implants and prostheses in the fields of orthodontics and orthopaedics, thanks to its high biocompatibility regarding low ion release. Titanium also has outstanding corrosion resistance, great mechanical properties in terms of high hardness, low modulus of elasticity, low density, and high fatigue limit, which is a requirement for most implants. The above-mentioned remarkable biocompatibility of titanium is related to the development of a native oxide layer on its surface when exposed to air. In addition, this layer can develop in certain arranged patterns, that prove to be useful for the local administration of antibacterial agents, thus offering an alternative to aggressive surgical procedures against implant-related infections. Indeed, the main causes of implant failure are prosthesis-related infections. Thus, the aim of this project is to prevent infection of titanium implants when embedded in the body by loading the titanium oxide layer with an antibacterial agent and to develop coatings to reach release close to the zero kinetic order. For this purpose, a specific titanium dioxide structure, titanium nanotubes, was developed using an electrochemical oxidation reaction, and studied by looking at the different parameters affecting their geometry. The nanotubes were then loaded with an antibacterial agent and coated with two different coatings. These coatings are intended to degrade gradually to allow the antibacterial agent to be released with a steady flow without causing an overdose and thus prevent the growth of bacterial biofilms. Titanium nanotubes samples were characterized using a Scanning Electron Microscope (SEM) allowing to see the influence of the growing parameters. Coatings were characterized using Fourier-Transform Infrared Spectroscopy (FTIR). Various bacteriological studies were carried to see the impact of the different parameters, including surface geometries and types of coatings. The results were analyzed and showed successful growth of nanotubes capable of storing a bactericidal agent. In addition, the coatings were developed with great success. Bacterial studies showed a great antibacterial effect of the coatings or antibacterial loaded nanotube samples. However, the aspect of zero-order diffusion will not have been addressed in this project.El titanio y sus aleaciones derivadas suscitan un interés creciente en el ámbito médico debido a las numerosas ventajas que parece poseer. En efecto, el titanio se utiliza ampliamente como material para implante y prótesis en los campos de la ortodoncia y la ortopedia, gracias a su elevada biocompatibilidad en cuanto a su baja liberación de iones. El titanio también posee una extraordinaria resistencia a la corrosión, grandes propiedades mecánicas en términos de alta dureza, bajo módulo de elasticidad, baja densidad y alto límite de fatiga, lo cual es un requisito para la mayoría de los implantes. La notable biocompatibilidad del titanio antes mencionada está relacionada con el desarrollo de una capa de óxido nativo en su superficie cuando se expone al aire. Además, esta capa puede desarrollarse en determinados patrones dispuestos, que resultan útiles para la administración local de agentes antibacterianos, ofreciendo así una alternativa a los procedimientos quirúrgicos agresivos contra infecciones vinculadas al implante. De hecho, las principales causas de fracaso de los implantes son las infecciones relacionadas con las prótesis. Así pues, el objetivo de este proyecto es prevenir la infección de implante de titanio cuando está implantado en el paciente cargando la capa de óxido de titanio con un agente antibacteriano y desarrollar recubrimientos que alcancen una liberación próxima al orden cinético cero. Para ello, se desarrolló una estructura específica de dióxido de titanio, los nanotubos de titanio, mediante una reacción de oxidación electroquímica, y se estudiaron los distintos parámetros que afectan a su geometría. A continuación, los nanotubos se cargaron con un agente antibacteriano y se recubrieron con dos recubrimientos diferentes. Estos recubrimientos están destinados a degradarse gradualmente para permitir que el agente antibacteriano se libere con un flujo constante sin causar una sobredosis y evitar así el crecimiento de biopelículas bacterianas. Las muestras de nanotubos de titanio se caracterizaron mediante microscopio electrónico de barrido (SEM) que permitió ver la influencia de los parámetros de crecimiento. Los recubrimientos se caracterizaron mediante espectroscopia infrarroja con transformada de Fourier (FTIR). Se llevaron a cabo varios estudios bacteriológicos para ver el impacto de los diferentes parámetros, incluidas las geometrías de superficie y los tipos de recubrimientos. Los resultados se analizaron y mostraron un crecimiento satisfactorio de nanotubos capaces de almacenar un agente bactericida. Además, los recubrimientos se desarrollaron con gran éxito. Los estudios bacteriológicos mostraron un gran efecto antibacteriano de los recubrimientos o de las muestras de nanotubos cargadas con antibacterianos. Sin embargo, en este proyecto no se abordó el estudio de la cinética de la difusión.Le titane et ses alliages dérivés suscitent un intérêt croissant dans le domaine médical en raison des nombreux avantages qu'il semble posséder. En effet, le titane est largement utilisé comme matériaux pour implants et prothèses dans les domaines de l'orthodontie et de l'orthopédie, grâce à sa grande biocompatibilité liée à sa faible libération d'ions. Le titane présente également une résistance exceptionnelle à la corrosion ainsi que des propriétés mécaniques importantes, comme une dureté élevée, un faible module d'élasticité, une faible densité et une limite de fatigue élevée, ces conditions étant des prérequis pour la plupart des implants. La remarquable biocompatibilité du titane susmentionnée est liée au développement d'une couche d'oxyde natif à sa surface lorsqu'il est exposé à l'air. En outre, cette couche peut se développer selon certains schémas arrangés, qui s'avèrent utiles pour l'administration locale d'agents antibactériens, offrant ainsi une alternative aux procédures chirurgicales agressives. En effet, les principales causes d'échec des implants sont les infections liées aux prothèses. Ainsi, l'objectif de ce projet est de prévenir l'infection d’implants en titane lorsqu'ils sont intégrés dans le patient en chargeant la couche d'oxyde de titane d'un agent antibactérien et de développer des revêtements permettant d'atteindre une libération de celui-ci proche de l'ordre cinétique zéro. À cette fin, une structure spécifique de dioxyde de titane, les nanotubes de titane, a été développée à l'aide d'une réaction d'oxydation électrochimique, et étudiée en examinant les différents paramètres affectant leur géométrie. Les nanotubes ont ensuite été chargés d'un agent antibactérien et recouverts de deux revêtements différents. Ces revêtements sont destinés à se dégrader progressivement pour permettre à l'agent antibactérien d'être libéré avec un débit régulier sans provoquer de surdosage et ainsi empêcher la croissance de biofilms bactériens. Les échantillons de nanotubes de titane ont été caractérisés à l'aide d'un microscope électronique à balayage (MEB) permettant de voir l'influence des paramètres de croissance. Les revêtements ont été caractérisés par spectroscopie infrarouge à transformée de Fourier (FTIR). Diverses études bactériologiques ont été réalisées pour voir l'impact des différents paramètres, notamment les géométries de surface et les types de revêtements. Les résultats ont été analysés et ont montré une croissance réussie des nanotubes capables de stocker un agent bactéricide. En outre, les revêtements ont été développés avec un grand succès. Les études bactériennes ont montré un effet antibactérien remarquable des revêtements ainsi que des échantillons de nanotubes chargés d'antibactériens. Cependant, l'étude de la cinétique de diffusion n'aura pas été abordé dans ce projet.IncomingUniversitat Politècnica de CatalunyaRodríguez Rius, Daniel20232023-02-1020232023-04-14master thesishttp://purl.org/coar/resource_type/c_bdccNAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/2117/386221reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3862212026-05-27T15:37:01Z
score 15,300719

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