Surface treatment of titanium with antibacterial properties for biomedical applications
Titanium and its derivative alloys are attracting increasing interest in the medical field due to the many advantages it appears to possess. Indeed, titanium is widely used as a biomaterial for implants and prostheses in the fields of orthodontics and orthopaedics, thanks to its high biocompatibilit...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/386221 |
| Acceso en línea: | https://hdl.handle.net/2117/386221 |
| Access Level: | acceso abierto |
| Palabra clave: | Titanium -- Medical applications Titanium surface treatment nanotubes biomedical Titani -- Aplicacions mèdiques Àrees temàtiques de la UPC::Enginyeria dels materials |
| Sumario: | Titanium and its derivative alloys are attracting increasing interest in the medical field due to the many advantages it appears to possess. Indeed, titanium is widely used as a biomaterial for implants and prostheses in the fields of orthodontics and orthopaedics, thanks to its high biocompatibility regarding low ion release. Titanium also has outstanding corrosion resistance, great mechanical properties in terms of high hardness, low modulus of elasticity, low density, and high fatigue limit, which is a requirement for most implants. The above-mentioned remarkable biocompatibility of titanium is related to the development of a native oxide layer on its surface when exposed to air. In addition, this layer can develop in certain arranged patterns, that prove to be useful for the local administration of antibacterial agents, thus offering an alternative to aggressive surgical procedures against implant-related infections. Indeed, the main causes of implant failure are prosthesis-related infections. Thus, the aim of this project is to prevent infection of titanium implants when embedded in the body by loading the titanium oxide layer with an antibacterial agent and to develop coatings to reach release close to the zero kinetic order. For this purpose, a specific titanium dioxide structure, titanium nanotubes, was developed using an electrochemical oxidation reaction, and studied by looking at the different parameters affecting their geometry. The nanotubes were then loaded with an antibacterial agent and coated with two different coatings. These coatings are intended to degrade gradually to allow the antibacterial agent to be released with a steady flow without causing an overdose and thus prevent the growth of bacterial biofilms. Titanium nanotubes samples were characterized using a Scanning Electron Microscope (SEM) allowing to see the influence of the growing parameters. Coatings were characterized using Fourier-Transform Infrared Spectroscopy (FTIR). Various bacteriological studies were carried to see the impact of the different parameters, including surface geometries and types of coatings. The results were analyzed and showed successful growth of nanotubes capable of storing a bactericidal agent. In addition, the coatings were developed with great success. Bacterial studies showed a great antibacterial effect of the coatings or antibacterial loaded nanotube samples. However, the aspect of zero-order diffusion will not have been addressed in this project. |
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