Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response

[Background] Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiatio...

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Autores: González-Serna, Alejandro, Corma-Gómez, Anaïs, Cano, Mercedes, Rubio-Sánchez, Ricardo, Martín-Sierra, Carmen, Rincón, Pilar, Martín-Carmona, Jesica, Pérez-García, Margarita, Pineda, Juan Antonio, Real, Luis Miguel, Macías, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/400697
Acceso en línea:http://hdl.handle.net/10261/400697
https://api.elsevier.com/content/abstract/scopus_id/105008110155
Access Level:acceso abierto
Palabra clave:DAA
SVR
Cellular aging
Liver stiffness
Telomere length
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spelling Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral ResponseGonzález-Serna, AlejandroCorma-Gómez, AnaïsCano, MercedesRubio-Sánchez, RicardoMartín-Sierra, CarmenRincón, PilarMartín-Carmona, JesicaPérez-García, MargaritaPineda, Juan AntonioReal, Luis MiguelMacías, JuanDAASVRCellular agingLiver stiffnessTelomere length[Background] Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation date are related to LS reduction upon achieving SVR.[Methods] In a prospective cohort study (GEHEP-011) we measured several parameters associated with cellular aging, such as telomere attrition, mitochondrial alterations, and soluble biomarkers associated with senescence-associated secretory phenotype at the DAA initiation date, and examined their associations with a significant (≥20%) LS decrease at the SVR time point.[Results] In total, 175 individuals were included in this study. In 101 (57.7%) patients, the LS reduction was ≥20% at SVR. In the multivariate analysis adjusted for sex, age, CXCL10, hsPCR, and CCL11 levels, greater relative telomere length (RTL) emerged as the sole variable independently associated with a significant LS decrease in SVR (1.102; 95% confidence interval, 1.001–1.1214; P = .047). Furthermore, changes in LS, including significant decrease, decrease <20%, or increase, were congruently associated with RTL (P = .011).[Conclusions] Greater RTL was independently associated with a significant LS reduction in SVR. Thus, increased cellular aging may be responsible for the absence of liver regeneration after HCV eradication. Further studies are required to assess the long-term effects of cellular aging after SVR.[Clinical Trials Registration] NCT04460157.This work was supported by Instituto de Salud Carlos III (ISCIII) (grant number PI20/01457 to A. G. S.), cofunded by European Regional Development Fund (ERDF), A Way to Make Europe.Peer reviewedOxford University PressInstituto de Salud Carlos IIIEuropean CommissionMinisterio de de Economía, Comercio y Empresa (España)González-Serna, Alejandro [0000-0002-0239-8417]Corma-Gómez, Anaïs [0000-0002-1078-0237]Cano, Mercedes [0000-0002-7710-0072]Rubio-Sánchez, Ricardo [0000-0002-6313-4191]Martín-Sierra, Carmen [0000-0001-5120-1054]Martín-Carmona, Jesica [0000-0001-6791-4745]Real, Luis Miguel [0000-0003-4932-7429]Macías, Juan [0000-0002-4778-790X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/400697https://api.elsevier.com/content/abstract/scopus_id/105008110155reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//PI12%2F01457The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1093/infdis/jiaf087https://doi.org/10.1093/infdis/jiaf087Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4006972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
title Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
spellingShingle Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
González-Serna, Alejandro
DAA
SVR
Cellular aging
Liver stiffness
Telomere length
title_short Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
title_full Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
title_fullStr Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
title_full_unstemmed Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
title_sort Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
dc.creator.none.fl_str_mv González-Serna, Alejandro
Corma-Gómez, Anaïs
Cano, Mercedes
Rubio-Sánchez, Ricardo
Martín-Sierra, Carmen
Rincón, Pilar
Martín-Carmona, Jesica
Pérez-García, Margarita
Pineda, Juan Antonio
Real, Luis Miguel
Macías, Juan
author González-Serna, Alejandro
author_facet González-Serna, Alejandro
Corma-Gómez, Anaïs
Cano, Mercedes
Rubio-Sánchez, Ricardo
Martín-Sierra, Carmen
Rincón, Pilar
Martín-Carmona, Jesica
Pérez-García, Margarita
Pineda, Juan Antonio
Real, Luis Miguel
Macías, Juan
author_role author
author2 Corma-Gómez, Anaïs
Cano, Mercedes
Rubio-Sánchez, Ricardo
Martín-Sierra, Carmen
Rincón, Pilar
Martín-Carmona, Jesica
Pérez-García, Margarita
Pineda, Juan Antonio
Real, Luis Miguel
Macías, Juan
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Ministerio de de Economía, Comercio y Empresa (España)
González-Serna, Alejandro [0000-0002-0239-8417]
Corma-Gómez, Anaïs [0000-0002-1078-0237]
Cano, Mercedes [0000-0002-7710-0072]
Rubio-Sánchez, Ricardo [0000-0002-6313-4191]
Martín-Sierra, Carmen [0000-0001-5120-1054]
Martín-Carmona, Jesica [0000-0001-6791-4745]
Real, Luis Miguel [0000-0003-4932-7429]
Macías, Juan [0000-0002-4778-790X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv DAA
SVR
Cellular aging
Liver stiffness
Telomere length
topic DAA
SVR
Cellular aging
Liver stiffness
Telomere length
description [Background] Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation date are related to LS reduction upon achieving SVR.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/400697
https://api.elsevier.com/content/abstract/scopus_id/105008110155
url http://hdl.handle.net/10261/400697
https://api.elsevier.com/content/abstract/scopus_id/105008110155
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//PI12%2F01457
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1093/infdis/jiaf087
https://doi.org/10.1093/infdis/jiaf087
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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