Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).

Podlesnikar, Tomaž; Pizarro, Gonzalo; Fernandez-Jimenez, Rodrigo; Montero-Cabezas, Jose M; Greif, Nina; Sanchez-Gonzalez, Javier; Bucciarelli-Ducci, Chiara; Marsan, Nina Ajmone; Fras, Zlatko; Bax, Jeroen J; Fuster, Valentin; Ibáñez, Borja; Delgado, Victoria

Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).

We aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myoca...

Descripción completa

Detalles Bibliográficos
Autores:	Podlesnikar, Tomaž, Pizarro, Gonzalo, Fernandez-Jimenez, Rodrigo, Montero-Cabezas, Jose M, Greif, Nina, Sanchez-Gonzalez, Javier, Bucciarelli-Ducci, Chiara, Marsan, Nina Ajmone, Fras, Zlatko, Bax, Jeroen J, Fuster, Valentin, Ibáñez, Borja, Delgado, Victoria
Tipo de recurso:	artículo
Fecha de publicación:	2020
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/10465
Acceso en línea:	http://hdl.handle.net/20.500.12105/10465
Access Level:	acceso abierto

id	ES_e44ce154342374ca3e1829eca092bbcc
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/10465
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).Podlesnikar, TomažPizarro, GonzaloFernandez-Jimenez, RodrigoMontero-Cabezas, Jose MGreif, NinaSanchez-Gonzalez, JavierBucciarelli-Ducci, ChiaraMarsan, Nina AjmoneFras, ZlatkoBax, Jeroen JFuster, ValentinIbáñez, BorjaDelgado, VictoriaWe aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myocardial infarction (STEMI) with feature-tracking cardiovascular magnetic resonance (CMR). A total of 191 patients with acute anterior STEMI enrolled in the METOCARD-CNIC randomized clinical trial were evaluated. LV infarct zone and remote zone circumferential strain were measured with feature-tracking CMR at 1 week and 6 months after STEMI. In the overall population, the infarct zone circumferential strain significantly improved from 1 week to 6 months after STEMI (- 8.6 ± 9.0% to - 14.5 ± 8.0%; P < 0.001), while no changes in the remote zone strain were observed (- 19.5 ± 5.9% to - 19.2 ± 3.9%; P = 0.466). Patients who received early intravenous metoprolol had significantly more preserved infarct zone circumferential strain compared to the controls at 1 week (P = 0.038) and at 6 months (P = 0.033) after STEMI, while no differences in remote zone strain were observed. The infarct zone circumferential strain was significantly impaired in patients with MVO and IMH compared to those without (P < 0.001 at 1 week and 6 months), however it improved between both time points regardless of the presence of MVO or IMH (P < 0.001). In patients who developed adverse LV remodeling (defined as ≥ 20% increase in LV end-diastolic volume) remote zone circumferential strain worsened between 1 week and 6 months after STEMI (P = 0.036), while in the absence of adverse LV remodeling no significant changes in remote zone strain were observed. Regional LV circumferential strain with feature-tracking CMR allowed comprehensive evaluation of the sequelae of an acute STEMI treated with primary percutaneous coronary intervention and demonstrated long-lasting cardioprotective effects of early intravenous metoprolol. ClinicalTrials.gov, NCT01311700. Registered 8 March 2011 - Retrospectively registered.BioMed Central (BMC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)Instituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Fundación ProCNICMinisterio de Ciencia, Innovación y Universidades (España)National Institute for Health Research (Reino Unido)20202020-06-1620202020-06-1120202020-06-11journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/10465reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES SEV-2015-0505 Not availableES SAF2015–71613-REDI Not availableES PI16 02110ES DTS17 00136ES PI13 01979open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/104652026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
title	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
spellingShingle	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy). Podlesnikar, Tomaž
title_short	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
title_full	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
title_fullStr	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
title_full_unstemmed	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
title_sort	Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).
dc.creator.none.fl_str_mv	Podlesnikar, Tomaž Pizarro, Gonzalo Fernandez-Jimenez, Rodrigo Montero-Cabezas, Jose M Greif, Nina Sanchez-Gonzalez, Javier Bucciarelli-Ducci, Chiara Marsan, Nina Ajmone Fras, Zlatko Bax, Jeroen J Fuster, Valentin Ibáñez, Borja Delgado, Victoria
author	Podlesnikar, Tomaž
author_facet	Podlesnikar, Tomaž Pizarro, Gonzalo Fernandez-Jimenez, Rodrigo Montero-Cabezas, Jose M Greif, Nina Sanchez-Gonzalez, Javier Bucciarelli-Ducci, Chiara Marsan, Nina Ajmone Fras, Zlatko Bax, Jeroen J Fuster, Valentin Ibáñez, Borja Delgado, Victoria
author_role	author
author2	Pizarro, Gonzalo Fernandez-Jimenez, Rodrigo Montero-Cabezas, Jose M Greif, Nina Sanchez-Gonzalez, Javier Bucciarelli-Ducci, Chiara Marsan, Nina Ajmone Fras, Zlatko Bax, Jeroen J Fuster, Valentin Ibáñez, Borja Delgado, Victoria
author2_role	author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) Instituto de Salud Carlos III Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) Fundación ProCNIC Ministerio de Ciencia, Innovación y Universidades (España) National Institute for Health Research (Reino Unido)
description	We aimed to evaluate the effect of early intravenous metoprolol treatment, microvascular obstruction (MVO), intramyocardial hemorrhage (IMH) and adverse left ventricular (LV) remodeling on the evolution of infarct and remote zone circumferential strain after acute anterior ST-segment elevation myocardial infarction (STEMI) with feature-tracking cardiovascular magnetic resonance (CMR). A total of 191 patients with acute anterior STEMI enrolled in the METOCARD-CNIC randomized clinical trial were evaluated. LV infarct zone and remote zone circumferential strain were measured with feature-tracking CMR at 1 week and 6 months after STEMI. In the overall population, the infarct zone circumferential strain significantly improved from 1 week to 6 months after STEMI (- 8.6 ± 9.0% to - 14.5 ± 8.0%; P < 0.001), while no changes in the remote zone strain were observed (- 19.5 ± 5.9% to - 19.2 ± 3.9%; P = 0.466). Patients who received early intravenous metoprolol had significantly more preserved infarct zone circumferential strain compared to the controls at 1 week (P = 0.038) and at 6 months (P = 0.033) after STEMI, while no differences in remote zone strain were observed. The infarct zone circumferential strain was significantly impaired in patients with MVO and IMH compared to those without (P < 0.001 at 1 week and 6 months), however it improved between both time points regardless of the presence of MVO or IMH (P < 0.001). In patients who developed adverse LV remodeling (defined as ≥ 20% increase in LV end-diastolic volume) remote zone circumferential strain worsened between 1 week and 6 months after STEMI (P = 0.036), while in the absence of adverse LV remodeling no significant changes in remote zone strain were observed. Regional LV circumferential strain with feature-tracking CMR allowed comprehensive evaluation of the sequelae of an acute STEMI treated with primary percutaneous coronary intervention and demonstrated long-lasting cardioprotective effects of early intravenous metoprolol. ClinicalTrials.gov, NCT01311700. Registered 8 March 2011 - Retrospectively registered.
publishDate	2020
dc.date.none.fl_str_mv	2020 2020-06-16 2020 2020-06-11 2020 2020-06-11
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/10465
url	http://hdl.handle.net/20.500.12105/10465
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	ES SEV-2015-0505 Not available ES SAF2015–71613-REDI Not available ES PI16 02110 ES DTS17 00136 ES PI13 01979
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	BioMed Central (BMC)
publisher.none.fl_str_mv	BioMed Central (BMC)
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869422578536284160
score	15,812455

Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy).

Similares en LA Referencia