Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction

We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI sub...

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Bibliographic Details
Authors: Gavara Doñate, Jose|||0000-0002-3483-7066, Merenciano, Héctor|||0000-0002-1734-0381, Llopis-Lorente, Jordi|||0000-0002-3958-8062, Molina-Garcia, Tamara, Perez-Solé, Nerea|||0000-0003-3527-0337, de Dios, Elena, Marcos-Garces, Víctor, Monmeneu, José V., Lopez-Lereu, María P., Canoves, Joaquim, Bonanad, Clara, Moratal, David|||0000-0002-2825-3646, Núñez, Julio|||0000-0003-1672-7119, Bayés-Genís, Antoni|||0000-0002-3044-197X, Sanchis, Juan|||0000-0003-0797-8709, Chorro, Francisco J., Rios-Navarro, Cesar|||0000-0002-6405-6279, Bodi, Vicente|||0000-0001-6425-5828
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:302144
Online Access:https://ddd.uab.cat/record/302144
https://dx.doi.org/urn:doi:10.3390/diagnostics14040368
Access Level:Open access
Keyword:ST-segment elevation myocardial infarction
Epicardial adipose tissue
Cardiovascular
Magnetic resonance
Infarct size
Left ventricular ejection fraction
Description
Summary:We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was 31 ± 13 mL/m. Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at 6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field.

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