Impact of phosphoproteomics in the translation of kinase-targeted therapies

[EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndrom...

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Detalhes bibliográficos
Autores: Casado, Pedro, Hijazi Vega, Maruan, Britton, David, Cutillas, Pedro R
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/155139
Acesso em linha:http://hdl.handle.net/10366/155139
Access Level:acceso embargado
Palavra-chave:Biomarkers
Cancer
Kinase inhibitors
Phosphoproteomics
Technology
Proteomics
Molecular Targeted Therapy
Animals
Humans
Protein Kinases
Protein Kinase Inhibitors
Biomedical Research
Phosphoproteins
fosfoproteínas
terapia molecular selectiva
inhibidores de proteína cinasas
animales
humanos
investigación biomédica
proteina cinasas
proteómica
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repository_id_str
spelling Impact of phosphoproteomics in the translation of kinase-targeted therapiesCasado, PedroHijazi Vega, MaruanBritton, DavidCutillas, Pedro RBiomarkersCancerKinase inhibitorsPhosphoproteomicsTechnologyProteomicsMolecular Targeted TherapyAnimalsHumansProtein KinasesProtein Kinase InhibitorsBiomedical ResearchPhosphoproteinsfosfoproteínasterapia molecular selectivainhibidores de proteína cinasasanimaleshumanosinvestigación biomédicaproteina cinasasproteómica[EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndromes. Phosphoproteomics is a technique that measures the products of kinase activities and, with the appropriate bioinformatics techniques, the methodology can also provide measures of kinase pathway activation and network circuitry. Hence, due to recent technological advantages, LC-MS-based quantitative phosphoproteomics provides relevant information for the design and implementation of kinase inhibitor based therapies. Here, we review how phosphoproteome profiling is being used in translational research as a means to identify drug targets and biomarkers for personalizing therapies based on kinase inhibitors.Wileyinfo202420242017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/155139reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1551392026-06-07T06:28:51Z
dc.title.none.fl_str_mv Impact of phosphoproteomics in the translation of kinase-targeted therapies
title Impact of phosphoproteomics in the translation of kinase-targeted therapies
spellingShingle Impact of phosphoproteomics in the translation of kinase-targeted therapies
Casado, Pedro
Biomarkers
Cancer
Kinase inhibitors
Phosphoproteomics
Technology
Proteomics
Molecular Targeted Therapy
Animals
Humans
Protein Kinases
Protein Kinase Inhibitors
Biomedical Research
Phosphoproteins
fosfoproteínas
terapia molecular selectiva
inhibidores de proteína cinasas
animales
humanos
investigación biomédica
proteina cinasas
proteómica
title_short Impact of phosphoproteomics in the translation of kinase-targeted therapies
title_full Impact of phosphoproteomics in the translation of kinase-targeted therapies
title_fullStr Impact of phosphoproteomics in the translation of kinase-targeted therapies
title_full_unstemmed Impact of phosphoproteomics in the translation of kinase-targeted therapies
title_sort Impact of phosphoproteomics in the translation of kinase-targeted therapies
dc.creator.none.fl_str_mv Casado, Pedro
Hijazi Vega, Maruan
Britton, David
Cutillas, Pedro R
author Casado, Pedro
author_facet Casado, Pedro
Hijazi Vega, Maruan
Britton, David
Cutillas, Pedro R
author_role author
author2 Hijazi Vega, Maruan
Britton, David
Cutillas, Pedro R
author2_role author
author
author
dc.subject.none.fl_str_mv Biomarkers
Cancer
Kinase inhibitors
Phosphoproteomics
Technology
Proteomics
Molecular Targeted Therapy
Animals
Humans
Protein Kinases
Protein Kinase Inhibitors
Biomedical Research
Phosphoproteins
fosfoproteínas
terapia molecular selectiva
inhibidores de proteína cinasas
animales
humanos
investigación biomédica
proteina cinasas
proteómica
topic Biomarkers
Cancer
Kinase inhibitors
Phosphoproteomics
Technology
Proteomics
Molecular Targeted Therapy
Animals
Humans
Protein Kinases
Protein Kinase Inhibitors
Biomedical Research
Phosphoproteins
fosfoproteínas
terapia molecular selectiva
inhibidores de proteína cinasas
animales
humanos
investigación biomédica
proteina cinasas
proteómica
description [EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndromes. Phosphoproteomics is a technique that measures the products of kinase activities and, with the appropriate bioinformatics techniques, the methodology can also provide measures of kinase pathway activation and network circuitry. Hence, due to recent technological advantages, LC-MS-based quantitative phosphoproteomics provides relevant information for the design and implementation of kinase inhibitor based therapies. Here, we review how phosphoproteome profiling is being used in translational research as a means to identify drug targets and biomarkers for personalizing therapies based on kinase inhibitors.
publishDate 2017
dc.date.none.fl_str_mv 2017
2024
2024
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/155139
url http://hdl.handle.net/10366/155139
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422569437790208
score 15,301603

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