Impact of phosphoproteomics in the translation of kinase-targeted therapies
[EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndrom...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/155139 |
| Acceso en línea: | http://hdl.handle.net/10366/155139 |
| Access Level: | acceso embargado |
| Palabra clave: | Biomarkers Cancer Kinase inhibitors Phosphoproteomics Technology Proteomics Molecular Targeted Therapy Animals Humans Protein Kinases Protein Kinase Inhibitors Biomedical Research Phosphoproteins fosfoproteínas terapia molecular selectiva inhibidores de proteína cinasas animales humanos investigación biomédica proteina cinasas proteómica |
| Sumario: | [EN]Signaling pathways driven by protein and lipid kinases are altered in most human diseases. Therefore, pharmacological inhibitors of cell signaling are one of the most intensively pursued therapeutic approaches for the treatment of diseases such as cancer, neurodegeneration, and metabolic syndromes. Phosphoproteomics is a technique that measures the products of kinase activities and, with the appropriate bioinformatics techniques, the methodology can also provide measures of kinase pathway activation and network circuitry. Hence, due to recent technological advantages, LC-MS-based quantitative phosphoproteomics provides relevant information for the design and implementation of kinase inhibitor based therapies. Here, we review how phosphoproteome profiling is being used in translational research as a means to identify drug targets and biomarkers for personalizing therapies based on kinase inhibitors. |
|---|