Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study
In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/29096 |
| Acceso en línea: | https://hdl.handle.net/10171/29096 |
| Access Level: | acceso abierto |
| Palabra clave: | Epigenetics Weight loss intervention Biomarkers Dieting response |
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Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON studyMoleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebCampión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817cMarcos, A. (Ascensión)|||/items/3819856a-a083-497b-9603-0f673a978740Campoy, C. (Cristina)|||/items/029daec1-bfbf-407b-bde4-116059a92af6Garagorri, J.M. (Jesús Maria)|||/items/e82b532e-c986-4ef7-b102-b0a56108dc55Gomez-Martinez, S. (Sonia)|||/items/94f4bc4a-0671-48a2-b4cf-d3fab009cbadMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131Azcona-San-Julián, M.C. (María Cristina)|||/items/89d7bb2f-b633-4413-bc4d-cddf6026e848Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670EpigeneticsWeight loss interventionBiomarkersDieting responseIn recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI-TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI-SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents.Federation of American Society of Experimental Biology (FASEB)Dadun. Depósito Académico Digital Universidad de Navarra20132013-04-2220132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleimage/jpegimage/jpegimage/jpegimage/jpegapplication/pdfimage/jpegapplication/pdfhttps://hdl.handle.net/10171/29096reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/290962026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| title |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| spellingShingle |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study Moleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70 Epigenetics Weight loss intervention Biomarkers Dieting response |
| title_short |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| title_full |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| title_fullStr |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| title_full_unstemmed |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| title_sort |
Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study |
| dc.creator.none.fl_str_mv |
Moleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Marcos, A. (Ascensión)|||/items/3819856a-a083-497b-9603-0f673a978740 Campoy, C. (Cristina)|||/items/029daec1-bfbf-407b-bde4-116059a92af6 Garagorri, J.M. (Jesús Maria)|||/items/e82b532e-c986-4ef7-b102-b0a56108dc55 Gomez-Martinez, S. (Sonia)|||/items/94f4bc4a-0671-48a2-b4cf-d3fab009cbad Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Azcona-San-Julián, M.C. (María Cristina)|||/items/89d7bb2f-b633-4413-bc4d-cddf6026e848 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 |
| author |
Moleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70 |
| author_facet |
Moleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Marcos, A. (Ascensión)|||/items/3819856a-a083-497b-9603-0f673a978740 Campoy, C. (Cristina)|||/items/029daec1-bfbf-407b-bde4-116059a92af6 Garagorri, J.M. (Jesús Maria)|||/items/e82b532e-c986-4ef7-b102-b0a56108dc55 Gomez-Martinez, S. (Sonia)|||/items/94f4bc4a-0671-48a2-b4cf-d3fab009cbad Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Azcona-San-Julián, M.C. (María Cristina)|||/items/89d7bb2f-b633-4413-bc4d-cddf6026e848 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 |
| author_role |
author |
| author2 |
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c Marcos, A. (Ascensión)|||/items/3819856a-a083-497b-9603-0f673a978740 Campoy, C. (Cristina)|||/items/029daec1-bfbf-407b-bde4-116059a92af6 Garagorri, J.M. (Jesús Maria)|||/items/e82b532e-c986-4ef7-b102-b0a56108dc55 Gomez-Martinez, S. (Sonia)|||/items/94f4bc4a-0671-48a2-b4cf-d3fab009cbad Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Azcona-San-Julián, M.C. (María Cristina)|||/items/89d7bb2f-b633-4413-bc4d-cddf6026e848 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Epigenetics Weight loss intervention Biomarkers Dieting response |
| topic |
Epigenetics Weight loss intervention Biomarkers Dieting response |
| description |
In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI-TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI-SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2013-04-22 2013 2013-01-01 2013 2013-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/29096 |
| url |
https://hdl.handle.net/10171/29096 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
image/jpeg image/jpeg image/jpeg image/jpeg application/pdf image/jpeg application/pdf |
| dc.publisher.none.fl_str_mv |
Federation of American Society of Experimental Biology (FASEB) |
| publisher.none.fl_str_mv |
Federation of American Society of Experimental Biology (FASEB) |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869422527455952896 |
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15.300724 |