Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study

In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that...

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Detalles Bibliográficos
Autores: Moleres, A. (Adriana)|||/items/f83af6e2-75d6-4841-87d9-82e40a3a2a70, Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb, Campión-Zabalza, J. (Javier)|||/items/e0303c16-4823-4c72-80a7-28a752b6817c, Marcos, A. (Ascensión)|||/items/3819856a-a083-497b-9603-0f673a978740, Campoy, C. (Cristina)|||/items/029daec1-bfbf-407b-bde4-116059a92af6, Garagorri, J.M. (Jesús Maria)|||/items/e82b532e-c986-4ef7-b102-b0a56108dc55, Gomez-Martinez, S. (Sonia)|||/items/94f4bc4a-0671-48a2-b4cf-d3fab009cbad, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Azcona-San-Julián, M.C. (María Cristina)|||/items/89d7bb2f-b633-4413-bc4d-cddf6026e848, Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/29096
Acceso en línea:https://hdl.handle.net/10171/29096
Access Level:acceso abierto
Palabra clave:Epigenetics
Weight loss intervention
Biomarkers
Dieting response
Descripción
Sumario:In recent years, epigenetic markers emerged as a new tool to understand the influence of lifestyle factors on obesity phenotypes. Adolescence is considered an important epigenetic window over a human's lifetime. The objective of this work was to explore baseline changes in DNA methylation that could be associated with a better weight loss response after a multidisciplinary intervention program in Spanish obese or overweight adolescents. Overweight or obese adolescents (n=107) undergoing 10 wk of a multidisciplinary intervention for weight loss were assigned as high or low responders to the treatment. A methylation microarray was performed to search for baseline epigenetic differences between the 2 groups (12 subjects/group), and MALDI-TOF mass spectrometry was used to validate (n=107) relevant CpG sites and surrounding regions. After validation, 5 regions located in or near AQP9, DUSP22, HIPK3, TNNT1, and TNNI3 genes showed differential methylation levels between high and low responders to the multidisciplinary weight loss intervention. Moreover, a calculated methylation score was significantly associated with changes in weight, BMI-SDS, and body fat mass loss after the treatment. In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents.

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