Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped fo...

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Detalhes bibliográficos
Autores: López-Mejías R, Genre F, Remuzgo-Martínez S, Robustillo-Villarino M, García-Bermúdez M, Llorca J, Corrales A, González Juanatey, Carlos, Ubilla B, Miranda Filloy, José Alberto, Mijares V, Pina T, Blanco R, Alegre-Sancho JJ, Ramírez Huaranga MA, Mínguez Sánchez MD, Tejera Segura B, Ferraz-Amaro I, Vicente E, Carmona FD, Castañeda S, Martín J, González-Gay Mantecón, Miguel Ángel
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/8076
Acesso em linha:http://hdl.handle.net/20.500.11940/8076
Access Level:acceso abierto
Palavra-chave:Adult
Aged
Alleles
Arthritis, Rheumatoid
Atherosclerosis
Carotid Arteries
Female
Follow-Up Studies
Gene Frequency
Genotype
Humans
Interleukin-33
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Interleukin-1 Type I
Risk
Ultrasonography
Descrição
Resumo:OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean +/- standard deviation (SD): 0.71 +/- 0.14 mm versus 0.76 +/- 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean +/- SD: 0.73 +/- 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean +/- SD: 0.72 +/- 0.16 mm versus 0.75 +/- 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.

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