Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA...

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Detalles Bibliográficos
Autores: López Mejías, Raquel, Corrales, Alfonso, Vicente, Esther F., Robustillo Villarino, Montserrat, González Juanatey, Carlos, Llorca Díaz, Javier, Genre, Fernanda, Remuzgo Martínez, Sara, Dierssen Sotos, Trinidad, Miranda-Filloy, José A., Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Ferraz Amaro, Iván, Gómez Vaquero, Carmen, Balsa, Alejandro, López Longo, Francisco J., Carreira, Patricia, González Alvaro, Isidoro, Ocejo Vinyals, J. Gonzalo, Rodríguez-Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Castañeda, Santos, Martín, Javier, González-Gay, Miguel A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125259
Acceso en línea:https://hdl.handle.net/2445/125259
Access Level:acceso abierto
Palabra clave:Aterosclerosi
Artritis reumatoide
Atherosclerosis
Rheumatoid arthritis
Descripción
Sumario:A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/ absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.

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